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SEN 177

Cat. No. 6979 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent glutaminyl cyclase inhibitor; disrupts binding of SIRP-α to CD47
化学名： 6'-Fluoro-2-[4-(4-methyl-4H-1,2,4-triazol-3-yl)-1-piperidinyl]-3,3'-bipyridine
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for SEN 177

SEN 177 is a potent glutaminyl cyclase (QPCT) inhibitor (IC50 = 53 nM). SEN 177 reduces aggregation of mutant huntingtin (mHTT) through inhibition of QPCT and reduces Q80 aggregates in vitro. Inhibition of QPCT also reduces aggregate formation in in vivo models of Huntington's disease. SEN 177 potently inhibits QPCT-like protein (IC50 = 13 nM) and disrupts binding of SIRP-α to CD47. The compound increases antibody-dependent cellular phagocytosis and cytotoxicity in cancer cell lines.

技术数据 for SEN 177

分子量 338.39
公式 C18H19FN6
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2117405-13-5
PubChem ID 91618245
InChI Key AJIAMIPUWJQSPR-UHFFFAOYSA-N
Smiles FC=1N=CC(=CC1)C2=CC=CN=C2N3CCC(C4=NN=CN4C)CC3

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SEN 177

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 6.77 20
ethanol 6.77 20

制备储备液 for SEN 177

以下数据基于产品分子量 338.39。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 14.78 mL 73.88 mL 147.76 mL
1 mM 2.96 mL 14.78 mL 29.55 mL
2 mM 1.48 mL 7.39 mL 14.78 mL
10 mM 0.3 mL 1.48 mL 2.96 mL

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参考文献 for SEN 177

参考文献是支持产品生物活性的出版物。

Jimenez-Sanchez et al (2015) siRNA screen identifies QPCT as a druggable target for Huntington's disease. Nat.Chem.Biol. 11 347 PMID: 25848931

Logtenberg et al (2019) Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRPα axis and a target for cancer immunotherapy. Nat.Med. 25 612 PMID: 30833751

If you know of a relevant reference for SEN 177, please let us know.

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关键词: SEN 177, SEN 177 supplier, SEN177, QPCT, glutaminyl, cyclase, inhibitors, potent, huntingtin, mHTT, Huntingtons, aggregates, CD47, SIRPa, SIRPalpha, Other, Transferases, Immune, Checkpoints, 6979, Tocris Bioscience

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