Senktide

Cat. No. 1068 8 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Tachykinin NK₃ agonist

纯度： ≥95% (HPLC)

引用文献 (8)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Senktide

Senktide is a NK₃ tachykinin receptor agonist. Causes direct excitation of dopamine neurons; enhances dopaminergic function. Induces locomotor activity.

技术数据 for Senktide

分子量	841.97
公式	C₄₀H₅₅N₇O₁₁S
序列	DFFGLM (Modifications: Asp-1 = Succinyl-Asp, Phe-3 = Me-Phe, Met-6 = C-terminal amide)
储存	Store at -20°C
纯度	≥95% (HPLC)
CAS Number	106128-89-6
PubChem ID	90479751
InChI Key	UGXWLDUHYDFTIA-QKUYTOGTSA-N
Smiles	CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CC1=CC=C(C)C=C1)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CC(O)=O)NC(=O)CCC(O)=O)C(N)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Senktide

溶解性	Soluble to 1 mg/ml in PBS (pH 7.4)

产品说明书 for Senktide

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Senktide

参考文献是支持产品生物活性的出版物。

Keegan et al (1992) The selective NK receptor agonist senktide excites a subpopulation of DA-sensitive neurones in the rat substantia nigra pars compacta in vitro. Br.J.Pharmacol. 105 3 PMID: 1375857

Nordquist et al (2008) The tachykinin NK₃ receptor agonist senktide induces locomotor activity in male Mongolian gerbils. Eur.J.Pharmacol. 600 87 PMID: 18930726

Renzetti et al (1991) Characterization of NK-3 binding sites in rat and guinea-pig cortical membranes by the selective ligand [³H]senktide. Neuropeptides 18 107 PMID: 1712430

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关键词: Senktide, Senktide supplier, Tachykinin, NK3, agonists, Receptors, Neurokinin, Receptor, 1068, Tocris Bioscience

8 篇 Senktide 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Senktide 的部分引用包括：

Zelikowsky et al (2018) The Neuropeptide Tac2 Controls a Distributed Brain State Induced by Chronic Social Isolation Stress. Cell 173 1265 PMID: 29775595

Fergani et al (2018) NKB signaling in the posterodorsal medial amygdala stimulates Gn release in a kisspeptin-independent manner in female mice. Elife 7 PMID: 30565563

León et al (2016) Direct Actions of Kisspeptins on GnRH Neurons Permit Attainment of Fertility but are Insufficient to Fully Preserve Gonadotropic Axis Activity. Endocrinology 6 19206 PMID: 26755241

Grachev et al (2012) GPR54-dependent stimulation of luteinizing hormone secretion by neurokinin B in prepubertal rats. Cereb Cortex 7 e44344 PMID: 23028524

Navarro et al (2015) The integrated hypothalamic tachykinin-kisspeptin system as a central coordinator for reproduction. Nat Commun 156 627 PMID: 25422875

Glidewell-Kenney et al (2013) Neurokinin B causes acute GnRH secretion and repression of GnRH transcription in GT1-7 GnRH neurons. Mol Endocrinol 27 437 PMID: 23393128

Howe et al (2004) Role of neurokinin 3 receptors in supraoptic vasopressin and oxyt. neurons. Sci Rep 24 10103 PMID: 15537880

Gallopin et al (2006) Cortical sources of CRF, NKB, and CCK and their effects on pyramidal cells in the neocortex. J Neurosci 16 1440 PMID: 16339088

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