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Submit ReviewSerotonin hydrochloride
说明： Endogenous 5-HT receptor agonist
别名： 5-Hydroxytryptamine,5-HT
化学名： 3-(2-Aminoethyl)-1H-indol-5-ol hydrochloride
纯度： ≥98% (HPLC)
生物活性 for Serotonin hydrochloride
Serotonin hydrochloride is an endogenous agonist at 5-HT receptors and endogenous substrate for 5-HT transporters. Neurotransmitter that has roles in regulation of mood, emesis, sexuality, sleep and appetite in vivo.
技术数据 for Serotonin hydrochloride
| 分子量 | 212.68 |
| 公式 | C10H12N2O.HCl |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 153-98-0 |
| PubChem ID | 160436 |
| InChI Key | MDIGAZPGKJFIAH-UHFFFAOYSA-N |
| Smiles | NCCC2=CNC1=CC=C(O)C=C12.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Serotonin hydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 21.27 | 100 | |
| DMSO | 21.27 | 100 |
制备储备液 for Serotonin hydrochloride
以下数据基于产品分子量 212.68。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.7 mL | 23.51 mL | 47.02 mL |
| 5 mM | 0.94 mL | 4.7 mL | 9.4 mL |
| 10 mM | 0.47 mL | 2.35 mL | 4.7 mL |
| 50 mM | 0.09 mL | 0.47 mL | 0.94 mL |
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产品说明书 for Serotonin hydrochloride
参考文献 for Serotonin hydrochloride
参考文献是支持产品生物活性的出版物。
Barnes and Sharp (1999) A review of central 5-HT receptors and their function. Neuropharmacology 38 1083 PMID: 10462127
If you know of a relevant reference for Serotonin hydrochloride, please let us know.
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关键词: Serotonin hydrochloride, Serotonin hydrochloride supplier, Endogenous, 5-HT, receptors, agonists, Non-selective, 5-Hydroxytryptamine, 5-HT3, Receptors, Transporters, 3547, Tocris Bioscience
27 篇 Serotonin hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Serotonin hydrochloride 的部分引用包括：
Yin et al (2017) Selective Modulation of Axonal Sodium Channel Subtypes by 5-HT1A Receptor in Cortical Pyramidal Neuron. Cereb Cortex 27 509 PMID: 26494800
Hooper et al (2016) Selective serotonin reuptake inhibitor exposure constricts the mouse ductus arteriosus in utero. Am J Physiol Heart Circ Physiol 311 H572 PMID: 27371685
Heath D et al (2021) Activation of PPG neurons following acute stressors differentially involves hindbrain serotonin in male rats. Neuropharmacology 187 108477 PMID: 33581143
Lin et al (2021) Gαi/o-coupled Htr2c in the paraventricular nucleus of the hypothalamus antagonizes the anorectic effect of serotonin agents. Cell Rep 37 109997 PMID: 34788630
Bocchio et al (2015) Increased serotonin transporter expression reduces fear and recruitment of parvalbumin interneurons of the amygdala. Neuropsychopharmacology 40 3015 PMID: 26052039
Robery et al (2011) Investigating the effect of emetic compounds on chemotaxis in Dictyostelium identifies a non-sentient model for bitter and hot tastant research. PLoS One 6 e24439 PMID: 21931717
Haynes et al (2015) A single pair of neurons links sleep to memory consolidation in Drosophila melanogaster. BMC Vet Res 4 PMID: 25564731
Bryan L et al (2022) Molecular insights into the regulation of constitutive activity by RNA editing of 5HT2C serotonin receptors. Cell Rep 40 111211 PMID: 35977511
Hongyan et al (2022) Bimodal modulation of short-term motor memory via dynamic sodium pumps in a vertebrate spinal cord. Curr Biol 32 1038-1048.e2 PMID: 35104440
Bernardo L et al (2022) Co-packaging of opposing neurotransmitters in individual synaptic vesicles in the central nervous system. Neuron 110 1371-1384.e7 PMID: 35120627
Gerhold et al (2015) Pronociceptive and antinociceptive effects of Bupren. in the spinal cord dorsal horn cover a dose range of four orders of magnitude. J Neurosci 35 9580 PMID: 26134641
Bart C et al (2019) Hypophagia induced by hindbrain serotonin is mediated through central GLP-1 signaling and involves 5-HT2C and 5-HT3 receptor activation. Neuropsychopharmacology 44 1742-1751 PMID: 30959513
Hao et al (2019) A Genetically Encoded Fluorescent Sensor for Rapid and Specific In Vivo Detection of Norepinephrine. Neuron 102 745-761.e8 PMID: 30922875
Gene J et al (2019) Differential serotonin transporter (5-HTT) and 5-HT2 receptor density in limbic and neocortical areas of adults and children with autism spectrum disorders: implications for selective serotonin reuptake inhibitor efficacy. J Neurochem 151 642-655 PMID: 31325179
Chang et al (2019) A Serotonin-Modulated Circuit Controls Sleep Architecture to Regulate Cognitive Function Independent of Total Sleep in Drosophila. Curr Biol 29 3635-3646.e5 PMID: 31668619
Thomas C et al (2019) Neuromodulator Signaling Bidirectionally Controls Vesicle Numbers in Human Synapses. Cell 179 498-513.e22 PMID: 31585084
Szabo (2018) Immunomodulatory capacity of the serotonin receptor 5-HT2B in a subset of human dendritic cells. Sci Rep 8 1765 PMID: 29379077
Sean P et al (2018) Subversion of Systemic Glucose Metabolism as a Mechanism to Support the Growth of Leukemia Cells. Cancer Cell 34 659-673.e6 PMID: 30270124
Wieland B et al (2020) Serotonin Receptor 2A Activation Promotes Evolutionarily Relevant Basal Progenitor Proliferation in the Developing Neocortex. Neuron 108 1113-1129.e6 PMID: 33080227
David S et al (2020) NACHO Engages N-Glycosylation ER Chaperone Pathways for α7 Nicotinic Receptor Assembly. Cell Rep 32 108025 PMID: 32783947
Sanjeev et al (2020) The Serotonin Neurotransmitter Modulates Virulence of Enteric Pathogens. Cell Host Microbe 28 41-53.e8 PMID: 32521224
Daftary et al (2012) Essential role of brain-derived neurotrophic factor in the regulation of serotonin transmission in the basolateral amygdala. Neuroscience 224 125 PMID: 22917617
Rawls et al (2010) 5-HT1A-like receptor activation inhibits abstinence-induced metha. withdrawal in planarians. Neurosci Lett 484 113 PMID: 20709144
Yang et al (2010) Activation of submucosal 5-HT(3) receptors elicits a somatostatin-dependent inhibition of ion secretion in rat colon. Br J Pharmacol 159 1623 PMID: 20233224
Matsui and Alvarez (2018) Cocaine Inhibition of Synaptic Transmission in the Ventral Pallidum Is Pathway-Specific and Mediated by Serotonin. Cell Rep 23 3852 PMID: 29949769
T et al (2015) Spontaneous activity and stretch-induced contractile differentiation are reduced in vascular smooth muscle of miR-143/145 knockout mice. Acta Physiol (Oxf) 215 133-43 PMID: 26052659
Bracha et al (2013) The expression and role of serotonin receptor 5HTR2A in canine osteoblasts and an osteosarcoma cell line. Am J Physiol Regul Integr Comp Physiol 9 251 PMID: 24330646
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Serotonin hydrochloride 的评论
平均评分: 5 (Based on 1 Review.)
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Works well and affordable.
By
Anonymous on 05/23/2019
分析类型： Ex Vivo
种属： Mouse
Excellent product and affordable. Worked quite effectively for our ephys work, robustly hyperpolarizing neurons in control condition as expected.
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.