Sertraline hydrochloride

Cat. No. 2395 3 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： 5-HT reuptake inhibitor

化学名： (1S,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine hydrochloride

纯度： ≥99% (HPLC)

引用文献 (3)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Sertraline hydrochloride

Sertraline is a potent and selective serotonin (5-HT) reuptake inhibitor (SSRI) that is an orally active antidepressant. Sertraline also decreases ergosterol biosynthesis and exhibits antifungal activity against Candida auris in vitro. Sertraline acts as an inhibitor of SHMT(serine hydroxymethyltransferase), inhibiting serine/glycine synthesis and proliferation of serine/glycine synthesis-dependent breast cancer cell lines in vitro and in vivo.

化合物库 for Sertraline hydrochloride

Sertraline hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for Sertraline hydrochloride

分子量	342.69
公式	C₁₇H₁₇Cl₂N.HCl
储存	Desiccate at RT
纯度	≥99% (HPLC)
CAS Number	79559-97-0
PubChem ID	63009
InChI Key	BLFQGGGGFNSJKA-XHXSRVRCSA-N
Smiles	ClC(C(Cl)=C3)=CC=[C@@]3[C@H]2C1=CC=CC=C1[C@@H](NC)CC2.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Sertraline hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	34.26	100
	ethanol	17.13	50

制备储备液 for Sertraline hydrochloride

以下数据基于产品分子量 342.69。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.92 mL	14.59 mL	29.18 mL
5 mM	0.58 mL	2.92 mL	5.84 mL
10 mM	0.29 mL	1.46 mL	2.92 mL
50 mM	0.06 mL	0.29 mL	0.58 mL

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产品说明书 for Sertraline hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Sertraline hydrochloride

参考文献是支持产品生物活性的出版物。

Koe et al (1983) Sertraline, 1S,4S-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthylamine, a new uptake inhibitor with selectivity for serotonin. J.Pharmacol.Exp.Ther. 226 686 PMID: 6310078

Heym and Koe (1988) Pharmacology of sertraline: a review. J.Clin.Psychiatry 49 40 PMID: 3045112

Doogan and Caillard (1988) Sertraline: a new antidepressant. J.Clin.Psychiatry. 49 46 PMID: 2842321

Gowri et al (2020) Sertraline as a promising antifungal agent: inhibition of growth and biofilm of Candida auris with special focus on the mechanism of action in vitro. J.Appl.Microbiol. 128 426 PMID: 31621139

Geeraerts et al (2021) Repurposing the antidepressant Sertraline as SHMT inhibitor to suppress serine/glycine synthesis-addicted breast tumor growth. Mol.Cancer Ther. 20 50 PMID: 33203732

If you know of a relevant reference for Sertraline hydrochloride, please let us know.

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3 篇 Sertraline hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Sertraline hydrochloride 的部分引用包括：

Pai et al (2015) Endogenous gradients of resting potential instructively pattern embryonic neural tissue via Notch signaling and regulation of proliferation. J Neurosci 35 4366 PMID: 25762681

Hooper et al (2016) Selective serotonin reuptake inhibitor exposure constricts the mouse ductus arteriosus in utero. Am J Physiol Heart Circ Physiol 311 H572 PMID: 27371685

Lyons et al (2016) Serotonin and Antidepressant SSRIs Inhibit Rat Neuroendocrine DA Neurons: Parallel Actions in the Lactotrophic Axis The journal of Neuroscience 36 7392 PMID: 27413150

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