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SHIN 1

Cat. No. 6998 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent SHMT inhibitor
化学名： 6-Amino-1,4-dihydro-4-[5-(hydroxymethyl)[1,1'-biphenyl]-3-yl]-3-methyl-4-(1-methylethyl)pyrano[2,3-c]pyrazole-5-carbonitrile
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for SHIN 1

SHIN 1 is a potent serine hydroxymethyltransferase (SHMT) inhibitor (IC50 values are 5 and 13 nM at SHMT1 and SHMT2, respectively). Inhibits growth of HCT-116 cells in vitro (IC50 = 870 nM). Unstable in liver microsome assays.

许可信息

Sold under license from Princeton University.

技术数据 for SHIN 1

分子量 400.48
公式 C24H24N4O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2146095-85-2
PubChem ID 134335083
InChI Key VVVOFJZXKJKHTD-UHFFFAOYSA-N
Smiles CC(C1(C2=CC(C3=CC=CC=C3)=CC(CO)=C2)C4=C(OC(N)=C1C#N)NN=C4C)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SHIN 1

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 20.02 50

制备储备液 for SHIN 1

以下数据基于产品分子量 400.48。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 4.99 mL 24.97 mL 49.94 mL
2.5 mM 1 mL 4.99 mL 9.99 mL
5 mM 0.5 mL 2.5 mL 4.99 mL
25 mM 0.1 mL 0.5 mL 1 mL

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参考文献 for SHIN 1

参考文献是支持产品生物活性的出版物。

Ducker et al (2017) Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma. Proc.Natl.Acad.Sci.U.S.A. 114 11404 PMID: 29073064

If you know of a relevant reference for SHIN 1, please let us know.

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关键词: SHIN 1, SHIN 1 supplier, SHIN1, SHMT1, SHMT2, serine, hydroxymethyl, transferase, inhibitors, inhibits, potent, THF, tetrahydrofolate, Other, Transferases, 6998, Tocris Bioscience

1 篇 SHIN 1 的引用文献

引用文献是使用了 Tocris 产品的出版物。 SHIN 1 的部分引用包括：

Vamsi K et al (2021) SARS-CoV-2 hijacks folate and one-carbon metabolism for viral replication. Nat Commun 12 1676 PMID: 33723254

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