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ShK-Dap22

Cat. No. 3220 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3220 has been discontinued.

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说明： Extremely potent and selective KV1.3 blocker; suppresses T cell activation in vitro
纯度： ≥95% (HPLC)
说明书
引用文献
评论 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for ShK-Dap22

ShK-Dap22 is an extremely potent KV1.3 channel blocker (Kd = 23 pM for mKV1.3 currents). Selective for KV1.3 over other mammalian potassium channels (IC50 values are 23, 1800, 10500, 37000 and 39000 pM for mKV1.3, mKV1.1, hKV1.6, mKV1.4 and rKV1.2 respectively, and >100000 pM for hKV1.5, mKV1.7, hKV3.1, rKV3.4 and hKCa4). Suppresses T cell activation in vitro (IC50 < 500 pM).

技术数据 for ShK-Dap22

分子量 4012.7
公式 C166H268N54O48S7
序列 RSCIDTIPKSRCTAFQCKHSMXYRLSFCRKTCGTC

(Modifications: Disulfide bridges: 3-35, 12-28, 17-32, X= Dap)
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 220384-25-8
PubChem ID 122187345
InChI Key PFWOJTLVNOZSGQ-RIMJLNMDSA-N
Smiles [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H]2CSSC[C@@H]3NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC4=CC=C(O)C=C4)NC(=O)[C@H](CN)NC(=O)[C@H](CCSC)NC(=O)[C@H](CO)NC(=O)[C@H](CC4=CNC=N4)NC(=O)[C@H](CCCCN)NC3=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N2)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC1=O)[C@@H](C)CC)[C@@H](C)O)[C@@H](C)CC)[C@@H](C)O)[C@@H](C)O)C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for ShK-Dap22

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参考文献 for ShK-Dap22

参考文献是支持产品生物活性的出版物。

Kalman et al (1998) ShK-Dap22, a potent KV1.3-specific immunosuppresive polypeptide. J.Biol.Chem. 273 32697 PMID: 9830012

Robbins et al (2005) Hypoxia modulates early events in T cell receptor-mediated activation in human T lymphocytes via KV1.3 channels. J.Physiol. 564 131 PMID: 15677684

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关键词: ShK-Dap22, ShK-Dap22 supplier, toxins, potassium, channels, Kv1.3, potent, selective, blockers, inhibitors, inhibits, immunosuppressives, T, cells, venoms, Voltage-Gated, Potassium, Channels, 3220, Tocris Bioscience

篇 ShK-Dap22 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 ShK-Dap22 的引用文献。

ShK-Dap22 的评论

平均评分: 5 (Based on 1 Review.)

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Great product with reproducible data.
By Sadequl Islam on 10/22/2018
分析类型： In Vitro
种属： Human

This compound was used in our cell culture lab to quantify blocking activity of Kv channels. It produced reproducible data in osteosarcoma cell line. Great product, hugely recommend.

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