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Submit ReviewSilodosin
说明： Selective α1A antagonist
化学名： 2,3-Dihydro-1-(3-hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-1H-indole-7-carboxamide
纯度： ≥98% (HPLC)
生物活性 for Silodosin
Silodosin is a selective α1A adrenoceptor antagonist (Ki = 0.036 nM). Displays >55 fold selectivity for α1A over α1B and α1D. Inhibits norepinephrine-induced [Ca2+]I increase in α1A expressing CHO cells (IC50 = 0.32 nM). Inhibits norepinephrine-induced contraction of isolated human prostate tissue.
化合物库 for Silodosin
Silodosin is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。
技术数据 for Silodosin
| 分子量 | 495.53 |
| 公式 | C25H32F3N3O4 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 160970-54-7 |
| PubChem ID | 5312125 |
| InChI Key | PNCPYILNMDWPEY-QGZVFWFLSA-N |
| Smiles | C[C@@H](NCCOC1=C(C=CC=C1)OCC(F)(F)F)CC2=CC(C(N)=O)=C3N(CCC3=C2)CCCO |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Silodosin
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 49.55 | 100 | |
| ethanol | 49.55 | 100 |
制备储备液 for Silodosin
以下数据基于产品分子量 495.53。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.02 mL | 10.09 mL | 20.18 mL |
| 5 mM | 0.4 mL | 2.02 mL | 4.04 mL |
| 10 mM | 0.2 mL | 1.01 mL | 2.02 mL |
| 50 mM | 0.04 mL | 0.2 mL | 0.4 mL |
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产品说明书 for Silodosin
参考文献 for Silodosin
参考文献是支持产品生物活性的出版物。
Shibata et al (1995) KMD-3213, a novel, potent, alpha 1a-adrenoceptor-selective antagonist: characterization using recombinant human alpha 1-adrenoceptors and native tissues. Mol.Pharmacol. 48 250 PMID: 7651358
Moriyama et al (1997) KMD-3213, a novel alpha1A-adrenoceptor antagonist, potently inhibits the functional alpha1-adrenoceptor in human prostate. Eur.J.Pharmacol. 331 39 PMID: 9274928
If you know of a relevant reference for Silodosin, please let us know.
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关键词: Silodosin, Silodosin supplier, alpha, 1a, adrenoceptor, adrenergic, receptor, antagonists, antagonism, KMD-3213, Adrenergic, Alpha-1, Receptors, 6663, Tocris Bioscience
1 篇 Silodosin 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Silodosin 的部分引用包括：
Wen Cheng et al (2022) A common variant in 11q23.3 associated with hyperlipidemia is mediated by the binding and regulation of GATA4. NPJ Genom Med 7 4 PMID: 35046404
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.