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Sipatrigine

Cat. No. 4044 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： NaV blocker; neuroprotective
别名： 619C89
化学名： 2-(4-Methyl-1-piperazinyl)-5-(2,3,5-trichlorophenyl)-4-pyrimidinamine
纯度： ≥99% (HPLC)
说明书
引用文献
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Sipatrigine

Sipatrigine is a blocker of voltage-dependent sodium channels (NaV). Inhibits glutamate release; displays neuroprotective activity in rat models of cerebral ischemia. Also thought to block Ca2+ channels. Analog of lamotrigine (Cat. No. 1611).

技术数据 for Sipatrigine

分子量 372.68
公式 C15H16Cl3N5
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 130800-90-7
PubChem ID 60803
InChI Key PDOCBJADCWMDGL-UHFFFAOYSA-N
Smiles ClC1=CC(Cl)=C(Cl)C(C2=C(N)N=C(N3CCN(C)CC3)N=C2)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Sipatrigine

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 37.27 100
ethanol 9.32 25

制备储备液 for Sipatrigine

以下数据基于产品分子量 372.68。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.68 mL 13.42 mL 26.83 mL
5 mM 0.54 mL 2.68 mL 5.37 mL
10 mM 0.27 mL 1.34 mL 2.68 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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参考文献 for Sipatrigine

参考文献是支持产品生物活性的出版物。

Leach et al (1993) BW619C89, a glutamate release inhibitor, protects against focal cerebral ischemic damage. Stroke 24 1063 PMID: 8100654

Graham et al (1994) Neuroprotective effects of a use-dependent blocker of voltage-dependent sodium channels, BW619C89, in rat middle cerebral artery occlusion. J.Pharmacol.Exp.Ther. 269 854 PMID: 7910213

Stefani et al (1998) On the inhibition of voltage activated calcium currents in rat cortical neurones by the neuroprotective agent 619C89. Br.J.Pharmacol. 125 1058 PMID: 9846645

If you know of a relevant reference for Sipatrigine, please let us know.

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关键词: Sipatrigine, Sipatrigine supplier, nav, voltage-dependent, sodium, Na+, channels, blockers, neuroprotective, 619C89, Voltage-gated, Sodium, Channels, 4044, Tocris Bioscience

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