主页 / 药理学 / Enzymes / Histone Deacetylases / Class III HDACs (Sirtuins) / Class III HDAC (Sirtuin) Inhibitors / SirReal 2

SirReal 2

Cat. No. 5457 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Selective inhibitor of SIRT2
化学名： 2-[(4,6-Dimethyl-2-pyrimidinyl)thio]-N-[5-(1-naphthalenylmethyl)-2-thiazolyl]acetamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for SirReal 2

SirReal 2 is a selective SIRT2 inhibitor (IC50 = 140 nM). Has minimal effect on SIRT1 and SIRT3-6. Increases α-tubulin acetylation levels in HeLa cells.

化合物库 for SirReal 2

SirReal 2 is also offered as part of the Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for SirReal 2

分子量 420.55
公式 C22H20N4OS2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 709002-46-0
PubChem ID 1096292
InChI Key MENNDDDTIIZDDN-UHFFFAOYSA-N
Smiles CC1=CC(C)=NC(SCC(NC2=NC=C(CC3=CC=CC4=C3C=CC=C4)S2)=O)=N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SirReal 2

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 42.05 100

制备储备液 for SirReal 2

以下数据基于产品分子量 420.55。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.38 mL 11.89 mL 23.78 mL
5 mM 0.48 mL 2.38 mL 4.76 mL
10 mM 0.24 mL 1.19 mL 2.38 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

参考文献 for SirReal 2

参考文献是支持产品生物活性的出版物。

Rumpf et al (2015) Selective SIRT2 inhibition by ligand-induced rearrangement of the active site. Nat.Commun. 6 6263 PMID: 25672491

If you know of a relevant reference for SirReal 2, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Class III HDAC (Sirtuin) Inhibitors

关键词: SirReal 2, SirReal 2 supplier, SirReal2, selective, SIRT2, inhibitors, inhibits, Sirtuin, Sir2-like, Family, Deacetylases, Class, III, HDACs, (Sirtuins), 5457, Tocris Bioscience

篇 SirReal 2 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 SirReal 2 的引用文献。 您是否知道使用了 Tocris SirReal 2 的优秀论文？ 请告知我们.

SirReal 2 的评论

目前没有该产品的评论。 Be the first to review SirReal 2 and earn rewards!

Have you used SirReal 2?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Rheumatoid Arthritis Poster

Rheumatoid Arthritis Poster

Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.