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说明： Selective HDAC11 inhibitor
化学名： N'-Hexadecylthiophene-2-carbohydrazide
纯度： ≥95% (HPLC)
生物活性 for SIS17
SIS17 is a selective HDAC11 inhibitor (IC50 = 0.83 μM). Inhibits demyristoylation of serine hydroxymethyl transferase 2 with no detectable activity at other HDAC subtypes. Combination with Oxaliplatin (Cat. No. 2623) increases cytotoxicity to K562 cells; improves survival of Oxaliplatin-treated 769P cells. Cell permeable.
技术数据 for SIS17
| 分子量 | 366.61 |
| 公式 | C21H38N2OS |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 2374313-54-7 |
| PubChem ID | 139035087 |
| InChI Key | HSHXDCVZWHOWCS-UHFFFAOYSA-N |
| Smiles | O=C(NNCCCCCCCCCCCCCCCC)C=1SC=CC1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for SIS17
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 3.67 | 10 |
制备储备液 for SIS17
以下数据基于产品分子量 366.61。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 27.28 mL | 136.38 mL | 272.77 mL |
| 0.5 mM | 5.46 mL | 27.28 mL | 54.55 mL |
| 1 mM | 2.73 mL | 13.64 mL | 27.28 mL |
| 5 mM | 0.55 mL | 2.73 mL | 5.46 mL |
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产品说明书 for SIS17
参考文献 for SIS17
参考文献是支持产品生物活性的出版物。
Son et al (2019) Activity-guided design of HDAC11-specific inhibitors. ACS Chem.Biol. 14 1393 PMID: 31264832
Li et al (2022) A pan-cancer analysis identifies HDAC11 as an immunological and prognostic biomarker. FASEB J. 36 e22326 PMID: 35657209
If you know of a relevant reference for SIS17, please let us know.
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关键词: SIS17, SIS17 supplier, SIS17, HDAC, HDAC11, inhibitors, inhibit, inhibits, selective, cytotoxicity, Class, IV, HDACs, 7969, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.
Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.
Epigenetics in Cancer Poster
This poster summarizes the main epigenetic targets in cancer. The dysregulation of epigenetic modifications has been shown to result in oncogenesis and cancer progression. Unlike genetic mutations, epigenetic alterations are considered to be reversible and thus make promising therapeutic targets.