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Class IV HDACs

Class IV proteins contain one member, HDAC11, which is involved in regulating protein stability of DNA replication factor CDT1 and interleukin 10 expression.

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文献 (3)
Gene Data

Class IV HDAC Inhibitors
Cat. No. 产品名称/活性
7969 SIS17
Selective HDAC11 inhibitor

HDAC classification

Superfamily Family Class Subclass Protein (human)
Arginase/deacetylase superfamily Histone deacetylase family Class I HDAC1, HDAC2, HDAC3, HDAC8
Class II Class IIa HDAC4, HDAC5, HDAC7, HDAC9
ClassIIb HDAC6, HDAC10
Class IV HDAC11
Deoxyhypusine synthase like NAD/FAD-binding domain superfamily Sir2 regulator family Class III I SIRT1, SIRT2, SIRT3
II SIRT4
III SIRT5
IV SIRT6, SIRT7

Literature for Class IV HDACs

Tocris offers the following scientific literature for Class IV HDACs to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Epigenetics Scientific Review

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.

Cell Cycle & DNA Damage Repair Poster

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.

Epigenetics in Cancer Poster

Epigenetics in Cancer Poster

This poster summarizes the main epigenetic targets in cancer. The dysregulation of epigenetic modifications has been shown to result in oncogenesis and cancer progression. Unlike genetic mutations, epigenetic alterations are considered to be reversible and thus make promising therapeutic targets.

Histone Deacetylase Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
Class 1
HDAC1 Human HDAC1 NM_004964 Q13547
Mouse Hdac1 NM_008228 O09106
Rat Hdac1 NM_001025409 Q4QQW4
HDAC2 Human HDAC2 NM_001527 Q92769
Mouse Hdac2 NM_008229 P70288
Rat Hdac2 NM_053447 Q99PA1
HDAC3 Human HDAC3 NM_003883 O15379
Mouse Hdac3 NM_010411 O88895
Rat Hdac3 NM_053448 Q6P6W3
HDAC8 Human HDAC8 NM_018486 Q9BY41
Mouse Hdac8 NM_027382 Q8VH37
Rat Hdac8 NM_001126373 XP_343805
Class 2
HDAC4 Human HDAC4 NM_006037 P56524
Mouse Hdac4 NM_207225 Q6NZM9
Rat Hdac4 XM_343629 Q99P99
HDAC5 Human HDAC5 NM_001015053 Q9UQL6
Mouse Hdac5 NM_001077696 Q9Z2V6
Rat Hdac5 XM_001081495 Q5RJZ2
HDAC6 Human HDAC6 NM_006044 Q9UBN7
Mouse Hdac6 NM_010413 Q9Z2V5
Rat Hdac6 XM_228753 Q99P97
HDAC7 Human HDAC7 NM_016596 Q9UFU7
Mouse Hdac7 NM_019572 Q8C2B3
Rat Hdac7a XM_345868 Q99P96
HDAC9 Human HDAC9 NM_058177 Q9UKV0
Mouse Hdac9 NM_024124 Q99N13
HDAC10 Human HDAC10 NM_032019 Q969S8
Mouse Hdac10 NM_199198 Q6P3E7
Rat Hdac10 NM_001035000 Q569C4
Class 4
HDAC11 Human HDAC11 NM_024827 Q96DB2
Mouse Hdac11 NM_144919 Q91WA3
Rat Hdac11 NM_001106610 XP_238362