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SJ 172550

Cat. No. 3929 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3929 has been discontinued.

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说明： MDMX inhibitor. Disrupts MDMX-p53 interaction
化学名： 2-[2-Chloro-4-[(1,5-dihydro-3-methyl-5-oxo-1-phenyl-4H-pyrazol-4-ylidene)methyl]-6-ethoxyphenoxy]acetic acid methyl ester
纯度： ≥99% (HPLC)
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生物活性 技术数据 说明书 参考文献

生物活性 for SJ 172550

MDMX inhibitor. Reversibly binds MDMX (EC50 = 2.3 μM). Inhibits the MDMX-p53 interaction in cultured retinoblastoma cells; frees p53 to induce apoptosis.

技术数据 for SJ 172550

分子量 428.87
公式 C22H21ClN2O5
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 431979-47-4
PubChem ID 1317464
InChI Key RKKFQJXGAQWHBZ-LICLKQGHSA-N
Smiles O=C(N(C3=CC=CC=C3)N=C2C)/C2=C/C1=CC(OCC)=C(OCC(OC)=O)C(Cl)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for SJ 172550

参考文献是支持产品生物活性的出版物。

Reed et al (2010) Identification and characterization of the first small molecule inhibitor of MDMX. J.Biol.Chem. 285 10786 PMID: 20080970

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关键词: SJ 172550, SJ 172550 supplier, disrupts, p53, MDMX, interaction, inhibitors, inhibits, SJ172550, NHPP-spermine, 3929, Tocris Bioscience

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Cell Cycle and DNA Damage Research Product Guide

Cell Cycle and DNA Damage Research Product Guide

This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:

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Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.

Pathways for SJ 172550

p53 Signaling Pathway

p53 Signaling Pathway

p53 signaling plays an important role in the co-ordination of the cellular response different types of stress such as DNA damage and hypoxia. The downstream signals lead to apoptosis, senescence and cell cycle arrest.