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SJFδ

Cat. No. 7267 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective p38δ PROTAC®
化学名： N-(3-Fluoro-4-((7-(2-(2-(2-(2-(((2S,4R)-4-hydroxy-1-((S)-3-methyl-2-(1-oxoisoindolin-2-yl)butanoyl)pyrrolidine-2-carboxamido)methyl)-5-(4-methylthiazol-5-yl)phenoxy)ethoxy)ethoxy)ethoxy)-6-methoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for SJFδ

SJFδ is a potent and selective PROTAC ® Degrader of p38δ (DC50 = 46.17 nM; Dmax = 99.41%). SJFδ comprises the multikinase inhibitor foretinib joined by a linker to a VHL ligand. Exhibits no significant degradation of p38α, β or γ. Selectively degrades p38δ in MDA-MB-231 cells.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

技术数据 for SJFδ

分子量 1168.28
公式 C62H63F2N7O12S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2254609-23-7
PubChem ID 137628678
InChI Key LYUUIIZKBMBNQV-CHOFKVETSA-N
Smiles COC1=CC2=C(C=C1OCCOCCOCCOC1=C(CNC(=O)[C@@H]3C[C@@H](O)CN3C(=O)[C@H](C(C)C)N3CC4=CC=CC=C4C3=O)C=CC(=C1)C1=C(C)N=CS1)N=CC=C2OC1=C(F)C=C(NC(=O)C2(CC2)C(=O)NC2=CC=C(F)C=C2)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SJFδ

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 58.41 50

制备储备液 for SJFδ

以下数据基于产品分子量 1168.28。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 1.71 mL 8.56 mL 17.12 mL
2.5 mM 0.34 mL 1.71 mL 3.42 mL
5 mM 0.17 mL 0.86 mL 1.71 mL
25 mM 0.03 mL 0.17 mL 0.34 mL

Molarity Calculator

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Reconstitution Calculator

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参考文献 for SJFδ

参考文献是支持产品生物活性的出版物。

Smith et al (2019) Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase. Nat.Commun. 10 131 PMID: 30631068

If you know of a relevant reference for SJFδ, please let us know.

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关键词: SJFd, SJFd supplier, protac, active, degraders, degrades, selective, potent, von, Hippel, Lindau, VHL, E3, ligases, targeted, protein, degradation, TPD, protacs, MAPK, p38delta, p38d, p38δ, p38, Mitogen, Activated, Protein, Kinase, (MAPK), Degraders, 7267, Tocris Bioscience

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该领域的文献

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TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Assays for Protein Degradation
  • Induced Proximity Tools
Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia