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Submit ReviewSKA 121
Discontinued Product
6398 has been discontinued.
View all Calcium-Activated Potassium (K<sub>Ca</sub>) Channels products.
说明： Positive allosteric modulator of KCa3.1 (IK) channels
化学名： 5-Methylnaphth[2,1-d]oxazol-2-amine
纯度： ≥98% (HPLC)
生物活性 for SKA 121
SKA 121 is a positive allosteric modulator of KCa3.1 (intermediate-conductance Ca2+-activated potassium) channels (EC50 = 109 nM). Displays 40-fold selectivity for KCa3.1 over KCa2.3, and 200 to 400-fold selectivity over KV and NaV channels. Potentiates bradykinin-induced vasodilation ex vivo. Lowers mean arterial blood pressure in normotensive and hypertensive mice.
技术数据 for SKA 121
| 分子量 | 198.23 |
| 公式 | C12H10N2O |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1820708-73-3 |
| PubChem ID | 91827362 |
| InChI Key | JEGUERWMMMQFJV-UHFFFAOYSA-N |
| Smiles | NC(O1)=NC2=C1C3=CC=CC=C3C(C)=C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for SKA 121
参考文献 for SKA 121
参考文献是支持产品生物活性的出版物。
Coleman et al (2014) New positive Ca2+-activated K+ channel gating modulators with selectivity for KCa3.1. Mol.Pharmacol. 86 342 PMID: 24958817
Oliván-Viguera et al (2016) Vascular reactivity profile of novel KCa 3.1-selective positive-gating modulators in the coronary vascular bed. Basic Clin.Pharmacol.Toxicol. 119 184 PMID: 26821335
关键词: SKA 121, SKA 121 supplier, SKA121, calcium, sensitive, activated, potassium, channel, positive, allosteric, modulators, modulates, kca3.1, intermediate, conductance, SK4, IK, blood, pressure, vasodilation, Ca2+-Activated, Potassium, Channels, 6398, Tocris Bioscience
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