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SKA 121

Cat. No. 6398 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Positive allosteric modulator of KCa3.1 (IK) channels
化学名： 5-Methylnaphth[2,1-d]oxazol-2-amine
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for SKA 121

SKA 121 is a positive allosteric modulator of KCa3.1 (intermediate-conductance Ca2+-activated potassium) channels (EC50 = 109 nM). Displays 40-fold selectivity for KCa3.1 over KCa2.3, and 200 to 400-fold selectivity over KV and NaV channels. Potentiates bradykinin-induced vasodilation ex vivo. Lowers mean arterial blood pressure in normotensive and hypertensive mice.

技术数据 for SKA 121

分子量 198.23
公式 C12H10N2O
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1820708-73-3
PubChem ID 91827362
InChI Key JEGUERWMMMQFJV-UHFFFAOYSA-N
Smiles NC(O1)=NC2=C1C3=CC=CC=C3C(C)=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SKA 121

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 19.82 100
ethanol 9.91 50

制备储备液 for SKA 121

以下数据基于产品分子量 198.23。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 5.04 mL 25.22 mL 50.45 mL
5 mM 1.01 mL 5.04 mL 10.09 mL
10 mM 0.5 mL 2.52 mL 5.04 mL
50 mM 0.1 mL 0.5 mL 1.01 mL

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参考文献 for SKA 121

参考文献是支持产品生物活性的出版物。

Coleman et al (2014) New positive Ca2+-activated K+ channel gating modulators with selectivity for KCa3.1. Mol.Pharmacol. 86 342 PMID: 24958817

Oliván-Viguera et al (2016) Vascular reactivity profile of novel KCa 3.1-selective positive-gating modulators in the coronary vascular bed. Basic Clin.Pharmacol.Toxicol. 119 184 PMID: 26821335

If you know of a relevant reference for SKA 121, please let us know.

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关键词: SKA 121, SKA 121 supplier, SKA121, calcium, sensitive, activated, potassium, channel, positive, allosteric, modulators, modulates, kca3.1, intermediate, conductance, SK4, IK, blood, pressure, vasodilation, Ca2+-Activated, Potassium, Channels, 6398, Tocris Bioscience

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