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Submit ReviewSKF 77434 hydrobromide
Discontinued Product
1662 has been discontinued.
View all D<sub>1</sub> and D<sub>5</sub> Receptors products.
说明： Selective D1-like partial agonist
化学名： 2,3,4,5-Tetrahydro-1-phenyl-3-(2-propenyl)-1H-3-benzazepine-7,8-diol hydrobromide
纯度： ≥99% (HPLC)
生物活性 for SKF 77434 hydrobromide
SKF 77434 hydrobromide is a selective dopamine D1-like receptor partial agonist (IC50 values are 19.7 and 2425 nM for binding to D1-like and D2-like receptors respectively). Centrally active following systemic administration in vivo.
许可信息
Sold for research purposes under agreement from GlaxoSmithKline
技术数据 for SKF 77434 hydrobromide
| 分子量 | 376.29 |
| 公式 | C19H21NO2.HBr |
| 储存 | Desiccate at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 300561-58-4 |
| PubChem ID | 11957703 |
| InChI Key | JWQRAXTWDYUBFI-UHFFFAOYSA-N |
| Smiles | Br.OC1=CC2=C(C=C1O)C(CN(CC=C)CC2)C1=CC=CC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for SKF 77434 hydrobromide
参考文献 for SKF 77434 hydrobromide
参考文献是支持产品生物活性的出版物。
Briggs et al (1991) Activation of the 5-HT1C receptor expressed in Xenopus oocytes by the benzazepines SCH 23390 and SKF 38393. Br.J.Pharmacol. 104 1038 PMID: 1687364
Meyer and Schults (1993) DA D1 receptor family agonists, SK&F38393, SK&F77434, and SK&F82958, differentially affect locomotor activities in rats. Pharmacol.Biochem.Behav. 46 269 PMID: 7903456
Neumeyer et al (1992) Stereoisomeric probes for the D1 DA receptor: synthesis and characterization of R-(+) and S-(-) enantiomers of 3-allyl-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine and its 6-bromo analogue. J.Med.Chem. 35 1466 PMID: 1533424
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关键词: SKF 77434 hydrobromide, SKF 77434 hydrobromide supplier, Selective, D1-like, partial, agonists, Dopamine, Receptors, D5, dopaminergic, SKF77434, hydrobromide, GlaxoSmithKline, GSK, D1, and, 1662, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.