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Submit ReviewSKF 82958 hydrobromide
Discontinued Product
5719 has been discontinued.
View all D<sub>1</sub> and D<sub>5</sub> Receptors products.
说明： D1 agonist
化学名： 6-Chloro-2,3,4,5-tetrahydro-1-phenyl-3-(2-propen-1-yl)-1H-3-benzazepine-7,8-diol hydrobromide
纯度： ≥98% (HPLC)
生物活性 for SKF 82958 hydrobromide
SKF 82958 hydrobromide is a D1 agonist. Increases renal blood flow in animal models and promotes contralateral rotation in rats with unilateral lesions of the substantia nigra. Also augments GABAB inhibitory post-synaptic potentials (ipsp) in ventral tegmental area in brain slices.
技术数据 for SKF 82958 hydrobromide
| 分子量 | 410.73 |
| 公式 | C19H20ClNO2.HBr |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 74115-01-8 |
| PubChem ID | 9909521 |
| InChI Key | WLXGFAVTAAQOFH-UHFFFAOYSA-N |
| Smiles | OC1=CC(C(C2=CC=CC=C2)CN(CC=C)CC3)=C3C(Cl)=C1O.Br |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for SKF 82958 hydrobromide
参考文献 for SKF 82958 hydrobromide
参考文献是支持产品生物活性的出版物。
Pfeiffer et al (1982) DArgic activity of substituted 6-chloro-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines. J.Med.Chem. 25 352 PMID: 7069713
Cameron and Williams (1993) DA D1 receptors facilitate transmitter release. Nature 366 344 PMID: 8247128
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关键词: SKF 82958 hydrobromide, SKF 82958 hydrobromide supplier, SKF82958, hydrobromide, dopamine, D1, agonists, agonism, and, D5, Receptors, 5719, Tocris Bioscience
1 篇 SKF 82958 hydrobromide 的引用文献
引用文献是使用了 Tocris 产品的出版物。 SKF 82958 hydrobromide 的部分引用包括：
Verharen et al (2019) Differential contributions of striatal dopamine D1 and D2 receptors to component processes of value-based decision making. Neuropsychopharmacology 44 2195 PMID: 31254972
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.