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Submit ReviewSKF 83822 hydrobromide
说明： Selective D1-like agonist
化学名： 6-Chloro-2,3,4,5-tetrahydro-1-(3-methylphenyl)-3-(2-propenyl)-1H-3-benzazepine-7,8-diol hydrobromide
纯度： ≥98% (HPLC)
生物活性 for SKF 83822 hydrobromide
SKF 83822 hydrobromide is a high affinity, selective dopamine D1-like receptor agonist. Ki values are 3.2, 3.1, 186, 66, 335, 1167, 1251 and 1385 nM at recombinant D1, D5, D2, D3, D4, 5-HT2A, α1A and α1B receptors respectively. Stimulates adenylyl cyclase (EC50 = 65 nM) but not phosphoinositide hydrolysis. Induces extreme arousal and hyperlocomotion following subcutaneous administration in monkeys.
技术数据 for SKF 83822 hydrobromide
| 分子量 | 424.76 |
| 公式 | C20H22ClNO2.HBr |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 74115-10-9 |
| PubChem ID | 12909789 |
| InChI Key | CFWPKYBBXBANLU-UHFFFAOYSA-N |
| Smiles | ClC1=C(O)C(O)=CC2=C1CCN(CC=C)CC2C3=CC=CC(C)=C3.Br |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for SKF 83822 hydrobromide
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| ethanol | 3.44 | 10 | |
| DMSO | 34.38 | 100 |
制备储备液 for SKF 83822 hydrobromide
以下数据基于产品分子量 424.76。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.35 mL | 11.77 mL | 23.54 mL |
| 5 mM | 0.47 mL | 2.35 mL | 4.71 mL |
| 10 mM | 0.24 mL | 1.18 mL | 2.35 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.47 mL |
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产品说明书 for SKF 83822 hydrobromide
参考文献 for SKF 83822 hydrobromide
参考文献是支持产品生物活性的出版物。
Undie et al (1994) Evidence for a distinct D1-like DA receptor that couples to activation of phosphoinositide metabolism in brain. J.Neurochem. 62 2045 PMID: 7908949
Peacock and Gerlach (2001) Aberrant behavioural effects of a DA D1 receptor antagonist and agonist in monkeys: evidence of uncharted DA D1 receptor actions. Biol.Psychiatry 50 501 PMID: 11600103
O'Sullivan et al (2004) SK&F 83822 distinguishes adenylyl cyclase from phospholipase C-coupled D1-like receptors: behavioural topography. Eur.J.Pharmacol. 486 273 PMID: 14985049
If you know of a relevant reference for SKF 83822 hydrobromide, please let us know.
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关键词: SKF 83822 hydrobromide, SKF 83822 hydrobromide supplier, Selective, D1-like, agonists, Dopamine, D1, Receptors, D5, dopaminergic, SKF83822, hydrobromide, and, 2075, Tocris Bioscience
3 篇 SKF 83822 hydrobromide 的引用文献
引用文献是使用了 Tocris 产品的出版物。 SKF 83822 hydrobromide 的部分引用包括：
Ruskin et al (2013) Ketogenic diet improves core symptoms of autism in BTBR mice. PLoS One 8 e65021 PMID: 23755170
Urizar et al (2011) CODA-RET reveals functional selectivity as a result of GPCR heteromerization. Neuropsychopharmacology 7 624 PMID: 21785426
Kramar et al (2014) DA in the dorsal hippocampus impairs the late consolidation of cocaine-associated memory. J Neurosci 39 1645 PMID: 24442095
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
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