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Submit ReviewSKF 83959 hydrobromide
Discontinued Product
2074 has been discontinued.
View all D<sub>1</sub> and D<sub>5</sub> Receptors products.
说明： D1-like partial agonist
化学名： 6-Chloro-2,3,4,5-tetrahydro-3-methyl-1-(3-methylphenyl)-1H-3-benzazepine-7,8-diol
纯度： ≥98% (HPLC)
生物活性 for SKF 83959 hydrobromide
SKF 83959 hydrobromide is a dopamine D1-like receptor partial agonist (Ki values are 1.18, 7.56, 920 and 399 nM for rat D1, D5, D2 and D3 receptors respectively). May act as an antagonist in vivo, producing anti-Parkinsonian effects and antagonizing the behavioral effects of cocaine. Shown to potentiate agonist binding of the σ1 receptor.
技术数据 for SKF 83959 hydrobromide
| 分子量 | 398.73 |
| 公式 | C18H20ClNO2.HBr |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 67287-95-0 |
| PubChem ID | 11957685 |
| InChI Key | FHYWNBUFNGHNCP-UHFFFAOYSA-N |
| Smiles | Br.CN1CCC2=C(C=C(O)C(O)=C2Cl)C(C1)C1=CC(C)=CC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for SKF 83959 hydrobromide
参考文献 for SKF 83959 hydrobromide
参考文献是支持产品生物活性的出版物。
Platt et al (2000) Dissociation of cocaine-antagonist properties and motoric effects of the D1 receptor partial agonists SKF 83959 and SKF 77434. J.Pharmacol.Exp.Ther. 293 1017 PMID: 10869406
Cools et al (2002) SKF 83959 is an antagonist of DA D1-like receptors in the prefrontal cortex and nucleus accumbens: a key to its antiparkinsonian effect in animals? Neuropharmacology 42 237 PMID: 11804620
Neumeyer et al (2003) Receptor affinities of DA D1 receptor-selective novel phenylbenzazepines. Eur.J.Pharmacol. 474 137 PMID: 12921854
Guo et al (2013) SKF83959 is a potent allosteric modulator of sigma-1 receptor. Mol.Pharmacol. 83 577 PMID: 23295385
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关键词: SKF 83959 hydrobromide, SKF 83959 hydrobromide supplier, D1-like, partial, agonists, Dopamine, D1, Receptors, D5, dopaminergic, SKF83959, hydrobromide, and, Sigma1, 2074, Tocris Bioscience
6 篇 SKF 83959 hydrobromide 的引用文献
引用文献是使用了 Tocris 产品的出版物。 SKF 83959 hydrobromide 的部分引用包括：
Cassar et al (2015) A DA receptor contributes to paraquat-induced neurotoxicity in Drosophila. Pharmacol Biochem Behav 24 197 PMID: 25158689
Shen et al (2015) The DA D1-D2 receptor heteromer exerts a tonic inhibitory effect on the expression of amphetamine-induced locomotor sensitization. Br J Pharmacol 128 33 PMID: 25444866
Huang et al (2012) SKF83959, an agonist of phosphatidylinositol-linked D(1)-like receptors, promotes ERK1/2 activation and cell migration in cultured rat astrocytes. Nat Chem Biol 7 e49954 PMID: 23185493
Fuenzalida et al (2014) DA D1 and corticotrophin-releasing hormone type-2α receptors assemble into functionally interacting complexes in living cells. PLoS One 171 5650 PMID: 25073922
Perreault et al (2015) Regulation of c-fos expression by the DA D1-D2 receptor heteromer. Neuroscience 285 194 PMID: 25446350
Perreault et al (2013) A physiological role for the DA D5 receptor as a regulator of BDNF and Akt signalling in rodent prefrontal cortex. Int J Neuropsychopharmacol 16 477 PMID: 22827965
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.