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SKF 86466 hydrochloride

Cat. No. 3866 1 次引用 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent and selective α2 antagonist
化学名： 6-Chloro-N-methyl-2,3,4,5-tetrahydro-1-H-3-benzazepine hydrochloride
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论 (1)
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for SKF 86466 hydrochloride

SKF 86466 hydrochloride is a potent and selective α2 antagonist at pre- and post-junctional α2-adrenoceptors (Ki values are 13 and 17 nM respectively). Exhibits antihypertensive activity in a rat model.

化合物库 for SKF 86466 hydrochloride

SKF 86466 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for SKF 86466 hydrochloride

分子量 232.15
公式 C11H14ClN.HCl
储存 Desiccate at RT
纯度 ≥98% (HPLC)
CAS Number 86129-54-6
PubChem ID 10220250
InChI Key JKQKVNMNAIFCFS-UHFFFAOYSA-N
Smiles CN2CCC1=CC=CC(Cl)=C1CC2.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SKF 86466 hydrochloride

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 23.21 100
DMSO 23.21 100

制备储备液 for SKF 86466 hydrochloride

以下数据基于产品分子量 232.15。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 4.31 mL 21.54 mL 43.08 mL
5 mM 0.86 mL 4.31 mL 8.62 mL
10 mM 0.43 mL 2.15 mL 4.31 mL
50 mM 0.09 mL 0.43 mL 0.86 mL

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产品说明书 for SKF 86466 hydrochloride

分析证书/产品说明书
化学品安全技术说明书

参考文献 for SKF 86466 hydrochloride

参考文献是支持产品生物活性的出版物。

Roesler et al (1986) Characterization of the antihypertensive activity of SK&F 86466, a selective alpha-2 antagonist, in the rat. J.Pharmacol.Exp.Ther. 236 1 PMID: 2867209

Schafers et al (1990) An evaluation of the alpha-adrenoceptor antagonism produced by SK&F 86466 in healthy normotensive males. Br.J.Clin.Pharmacol. 30 884 PMID: 1981137

Hieble et al (1985) Selective alpha-2 adrenoceptor blockade by SK&F 86466: in vitro characterization of receptor sensitivity. J.Pharmacol.Exp.Ther. 236 90 PMID: 2867217

If you know of a relevant reference for SKF 86466 hydrochloride, please let us know.

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关键词: SKF 86466 hydrochloride, SKF 86466 hydrochloride supplier, Selective, α2-adrenoceptor, alpha2-adrenoceptor, a2-adrenoceptor, antagonist, α2-Adrenergic, alpha2-Adrenergic, a2-adrenergic, Receptors, SKF86466, SK&F, 86466, SKF, Adrenergic, Alpha-2, 3866, Tocris Bioscience

1 篇 SKF 86466 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 SKF 86466 hydrochloride 的部分引用包括：

Zeltner et al (2016) Capturing the biology of disease severity in a PSC-based model of familial dysautonomia. Nat Med 22 1421 PMID: 27841875

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SKF 86466 hydrochloride 的评论

平均评分: 4 (Based on 1 Review.)

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Worked great and at a nice price..
By Anonymous on 06/30/2020
分析类型： In Vitro
种属： Human
细胞系/组织： Human PSC

Great for passaging hPSCs with dissociation into single cells with 10 μM.

review image

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