SKF 89976A hydrochloride

Cat. No. 1081 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Potent GAT-1 inhibitor; brain penetrant

化学名： 1-(4,4-Diphenyl-3-butenyl)-3-piperidinecarboxylic acid hydrochloride

纯度： ≥99% (HPLC)

引用文献 (1)

文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for SKF 89976A hydrochloride

SKF 89976A hydrochloride is a potent GABA uptake inhibitor, selective for GAT-1 (IC₅₀ values are 0.13, 550, 944 and 7210 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively). Inhibits transport current competitively (K_i = 7 μM) and transmitter-gated current non-competitively (K_i = 0.03 nM). Able to pass the blood-brain barrier after systemic administration and is active in vivo.

许可信息

Sold with the permission of GlaxoSmithKline

化合物库 for SKF 89976A hydrochloride

SKF 89976A hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for SKF 89976A hydrochloride

分子量	371.91
公式	C₂₂H₂₅NO₂.HCl
储存	Desiccate at +4°C
纯度	≥99% (HPLC)
CAS Number	85375-15-1
PubChem ID	6917797
InChI Key	SNGGBKYQZVAQKA-UHFFFAOYSA-N
Smiles	Cl[H].OC(=O)C1CCCN(CC\C=C(\C2=CC=CC=C2)C2=CC=CC=C2)C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SKF 89976A hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water		100 温和加热
	DMSO	37.19	100

制备储备液 for SKF 89976A hydrochloride

以下数据基于产品分子量 371.91。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.69 mL	13.44 mL	26.89 mL
5 mM	0.54 mL	2.69 mL	5.38 mL
10 mM	0.27 mL	1.34 mL	2.69 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

产品说明书 for SKF 89976A hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for SKF 89976A hydrochloride

参考文献是支持产品生物活性的出版物。

Ali et al (1985) Orally active and potent inhibitors of γ-aminobutyric acid. J.Med.Chem. 28 653 PMID: 2985785

Krause and Schwarz (2005) Identification and selective inhibition of the channel mode of the neuronal GABA transporter 1. Mol.Pharmacol. 68 1728 PMID: 16150932

Murali Dha (1996) On the bioactive conformation of the GABA uptake inhibitor SK&F 89976-A. Bioorg.Med.Chem.Lett. 6 1535

If you know of a relevant reference for SKF 89976A hydrochloride, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 GABA Inhibitors

关键词: SKF 89976A hydrochloride, SKF 89976A hydrochloride supplier, Potent, GABA, reuptake, inhibitors, inhibits, Penetrates, blood, brain, barrier, GAT-1, Transporters, Monoamine, Neurotransmitter, SKF89976A, hydrochloride, GlaxoSmithKline, GSK, 1081, Tocris Bioscience

1 篇 SKF 89976A hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 SKF 89976A hydrochloride 的部分引用包括：

Sousa et al (2011) Regulation of hippocampal cannabinoid CB1 receptor actions by adenosine A1 receptors and chronic caffeine administration: implications for the effects of δ9-tetrahydrocannabinol on spatial memory. Neuropsychopharmacology 36 472 PMID: 20927050

您是否知道使用了 Tocris SKF 89976A hydrochloride 的优秀论文？请告知我们.

SKF 89976A hydrochloride 的评论

目前没有该产品的评论。 Be the first to review SKF 89976A hydrochloride and earn rewards!

Have you used SKF 89976A hydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

GABA Receptors Scientific Review

Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.