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Submit ReviewSKF 91488 dihydrochloride is a homolog of dimaprit (Cat. No. 0506); strong inhibitor of histamine N-methyltransferase. Exhibits no histamine agonist activity.
分子量 | 248.21 |
公式 | C7H17N3S.2HCl |
储存 | Desiccate at RT |
CAS Number | 68941-21-9 |
PubChem ID | 11957708 |
InChI Key | NPLHSMBWWIIWAQ-UHFFFAOYSA-N |
Smiles | CN(CCCCSC(=N)N)C.Cl.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
参考文献是支持产品生物活性的出版物。
Aiello et al (1997) Effects of two histamine-N-methyltransferase inhibitors, SKF 91488 and BW 301U, in rodent antinociception. Naunyn Schmiedebergs Arch.Pharmacol. 355 354 PMID: 9089666
Beaven and Shaff (1979) New inhibitors of histamine N-methyl-transferase. Biochem.Pharmacol. 28 183 PMID: 34400
Beaven and Shaff (1979) Inhibition of histamine methylation in vivo by the dimaprit analog SKF compound 91488. Agents Actions 9 455 PMID: 161853
Ohuri et al (1992) Histamine N-methyl transferase controls the contractile response of guinea pig trachea to histamine. J.Pharmacol.Exp.Ther. 261 1268 PMID: 1534842
关键词: SKF 91488 dihydrochloride, SKF 91488 dihydrochloride supplier, Histamine, N-methyltransferase, inhibitors, inhibits, transferases, Histaminergic-related, Compounds, Receptors, SKF91488, dihydrochloride, Other, Transferases, Histaminergic-Related, 0512, Tocris Bioscience
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