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Submit ReviewSN 38
说明： DNA topoisomerase I inhibitor; antitumor
别名： 7-Ethyl-10-hydroxycamptothecin
化学名： (4S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)dione
纯度： ≥98% (HPLC)
生物活性 for SN 38
SN 38 is an active metabolite of CPT-11 (Cat. No. 2688) that inhibits DNA topoisomerase I (IC50 values are 0.74 and 1.9 μM in P388 and Ehrlich cells respectively). Inhibits DNA and RNA synthesis (IC50 values are 0.077 and 1.3 μM respectively) but does not affect protein synthesis. Displays potent antitumor activity against a range of human tumor cell lines (IC50 values are 3.3, 13, 19 and 22 nM for HCT-116, BEL-7402, HL60 and HELA cells respectively).
化合物库 for SN 38
SN 38 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。
技术数据 for SN 38
| 分子量 | 392.4 |
| 公式 | C22H20N2O5 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 86639-52-3 |
| PubChem ID | 104842 |
| InChI Key | FJHBVJOVLFPMQE-QFIPXVFZSA-N |
| Smiles | OC1=CC=C(N=C(C(N3C4)=CC([C@](CC)(O)C(OC5)=O)=C5C3=O)C4=C2CC)C2=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for SN 38
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 19.62 | 50 |
制备储备液 for SN 38
以下数据基于产品分子量 392.4。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 5.1 mL | 25.48 mL | 50.97 mL |
| 2.5 mM | 1.02 mL | 5.1 mL | 10.19 mL |
| 5 mM | 0.51 mL | 2.55 mL | 5.1 mL |
| 25 mM | 0.1 mL | 0.51 mL | 1.02 mL |
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产品说明书 for SN 38
参考文献 for SN 38
参考文献是支持产品生物活性的出版物。
Kawato et al (1991) Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11. Cancer Res. 51 4187 PMID: 1651156
Gao et al (2005) Synthesis and antitumor activity of the hexacyclic camptothecin derivatives. Bioorg.Med.Chem.Lett. 15 3233 PMID: 15913996
Koizumi et al (2006) Novel SN-38-incorporating ploymeric micelles, NK012, eradicate vascular endothelial growth factor-Secr.g bulky tumors. Cancer Res. 66 10048 PMID: 17047068
If you know of a relevant reference for SN 38, please let us know.
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关键词: SN 38, SN 38 supplier, DNA, topoisomerase, I, inhibitors, inhibits, antitumor, Isomerases, SN38, chemotherapeutics, 7-Ethyl-10-hydroxycamptothecin, Topoisomerase, 2684, Tocris Bioscience
10 篇 SN 38 的引用文献
引用文献是使用了 Tocris 产品的出版物。 SN 38 的部分引用包括：
Guillon et al (2019) Regulation of senescence escape by TSP1 and CD47 following chemotherapy treatment. Cell Death Dis 10 199 PMID: 30814491
Ni et al (2011) Identification of proline residues in or near the transmembrane helices of the human breast cancer resistance protein (BCRP/ABCG2) that are important for transport activity and substrate specificity. Biochemistry 50 8057 PMID: 21854076
Prill et al (2019) Tumor-associated macrophages and individual chemo-susceptibility are influenced by iron chelation in human slice cultures of gastric cancer. Oncotarget 10 4731 PMID: 31413815
Ni et al (2010) Transmembrane helices 1 and 6 of the human breast cancer resistance protein (BCRP/ABCG2): identification of polar residues important for drug transport. Am J Physiol Cell Physiol 299 C1100 PMID: 20739628
Kathawala et al (2014) Masitinib antagonizes ATP-binding cassette subfamily G member 2-mediated multidrug resistance. Int J Oncol 44 1634 PMID: 24626598
Chen et al (2014) Enzymatic methylation and structure-activity-relationship studies on polycarcin V, a gilvocarcin-type antitumor agent. Chembiochem 15 2729 PMID: 25366963
Vétillard et al (2015) Akt inhibition improves irino. treatment and prevents cell emergence by switching the senescence response to apoptosis. Exp Neurol 6 43342 PMID: 26485768
Duff et al (2018) Regulation of senescence escape by the cdk4-EZH2-AP2M1 pathway in response to chemotherapy. Cell Death Dis 9 199 PMID: 29415991
Wolff et al (2018) Camptothecin exhibits topoisomerase1-independent KMT1A suppression and myogenic differentiation in alveolar rhabdomyosarcoma cells. Oncotarget 9 25796 PMID: 29899822
Jonchère et al (2015) Irinotecan treatment and senescence failure promote the emergence of more transformed and invasive cells that depend on anti-apoptotic Mcl-1. Oncotarget 6 409 PMID: 25565667
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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