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Submit ReviewSNC 80
说明： Highly selective non-peptide δ agonist
化学名： (+)-4-[(αR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide
纯度： ≥98% (HPLC)
生物活性 for SNC 80
SNC 80 is a highly selective and potent non-peptide δ-opioid agonist, 2000-fold selective over μ-opioid receptors.
化合物库 for SNC 80
SNC 80 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for SNC 80
| 分子量 | 449.64 |
| 公式 | C28H39N3O2 |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 156727-74-1 |
| PubChem ID | 123924 |
| InChI Key | KQWVAUSXZDRQPZ-UMTXDNHDSA-N |
| Smiles | [H][C@@](N1C[C@@H](C)N(CC=C)C[C@@H]1C)(C1=CC=C(C=C1)C(=O)N(CC)CC)C1=CC=CC(OC)=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for SNC 80
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| 1eq. HCl | 44.96 | 100 温和加热 | |
| DMSO | 8.99 | 20 |
制备储备液 for SNC 80
以下数据基于产品分子量 449.64。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.22 mL | 11.12 mL | 22.24 mL |
| 5 mM | 0.44 mL | 2.22 mL | 4.45 mL |
| 10 mM | 0.22 mL | 1.11 mL | 2.22 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
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产品说明书 for SNC 80
参考文献 for SNC 80
参考文献是支持产品生物活性的出版物。
Bilsky et al (1995) SNC 80, a selective, nonpeptidic and systemically active opioid δ agonist. J.Pharmacol.Exp.Ther. 273 359 PMID: 7714789
Calderon et al (1994) Probes for narcotic receptor mediated phenomena. 19. Synthesis of (+)-4-[(αR)-α-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide (SNC80): a highly selective nonpeptid J.Med.Chem. 37 2125 PMID: 8035418
Knapp et al (1996) Structure-activity relationships for SNC80 and related compounds at cloned human delta and mu opioid receptors. J.Pharmacol.Exp.Ther. 277 1284 PMID: 8667189
If you know of a relevant reference for SNC 80, please let us know.
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关键词: SNC 80, SNC 80 supplier, selective, non-peptide, δ-opioid, delta-opioid, agonists, DOP, Receptors, OP1, SNC80, Delta, Opioid, 0764, Tocris Bioscience
18 篇 SNC 80 的引用文献
引用文献是使用了 Tocris 产品的出版物。 SNC 80 的部分引用包括：
Milan-Lobo et al (2013) Anti-analgesic effect of the mu/delta opioid receptor heteromer revealed by ligand-biased antagonism. PLoS One 8 e58362 PMID: 23554887
Robins et al (2018) Critical Role for Gi/o-Protein Activity in the Dorsal Striatum in the Reduction of Voluntary Alcohol Intake in C57Bl/6 Mice. Front Psychiatry 9 112 PMID: 29686629
Burbassi et al (2010) Alterations of CXCR4 function in μ-opioid receptor-deficient glia. Eur J Neurosci 32 1278 PMID: 20880358
Scherrer et al (2006) Knockin mice expressing fluorescent delta-opioid receptors uncover G protein-coupled receptor dynamics in vivo. Proc Natl Acad Sci U S A 103 9691 PMID: 16766653
Wang et al (2018) Functional Divergence of Delta and Mu Opioid Receptor Organization in CNS Pain Circuits. Neuron 98 90 PMID: 29576387
Pacheco et al (2008) The mu-opioid receptor agonist morphine, but not agonists at delta- or kappa-opioid receptors, induces peripheral antinociception mediated by cannabinoid receptors. Br J Pharmacol 154 1143 PMID: 18469844
Pradhan et al (2014) δ-Opioid receptor agonists inhibit migraine-related hyperalgesia, aversive state and cortical spreading depression in mice. Br J Pharmacol 171 2375 PMID: 24467301
Markkanen and Petäjä-Repo (2008) N-glycan-mediated quality control in the endoplasmic reticulum is required for the expression of correctly folded delta-opioid receptors at the cell surface. J Biol Chem 283 29086 PMID: 18703511
Neumann et al (2015) The δ-opioid receptor affects epidermal homeostasis via ERK-dependent inhibition of transcription factor POU2F3. J Invest Dermatol 135 471 PMID: 25178105
Pacheco et al (2009) Central antinociception induced by mu-opioid receptor agonist morphine, but not delta- or kappa-, is mediated by cannabinoid CB1 receptor. Br J Pharmacol 158 225 PMID: 19594755
Sluka et al (2002) Chronic muscle pain induced by repeated acid Injection is reversed by spinally administered mu- and delta-, but not kappa-, opioid receptor agonists. J Pharmacol Exp Ther 302 1146 PMID: 12183674
Gomes et al (2000) Heterodimerization of μ and δ opioid receptors: A role in opiate synergy. Br J Pharmacol 20 RC110 PMID: 11069979
Ye (2017) Alterations in opioid inhibition cause widespread nociception but do not affect anxiety-like behavior in oral cancer mice. Neuroscience 363 50 PMID: 28673713
Ong et al (2015) Prolonged mor. treatment alters δ opioid receptor post-internalization trafficking. Front Endocrinol (Lausanne) 172 615 PMID: 24819092
Levoye et al (2015) A Broad G Protein-Coupled Receptor Internalization Assay that Combines SNAP-Tag Labeling, Diffusion-Enhanced Resonance Energy Transfer, and a Highly Emissive Terbium Cryptate. Brain Struct Funct 6 167 PMID: 26617570
Erbs et al (2015) A μ-δ opioid receptor brain atlas reveals neuronal co-occurrence in subcortical networks. J Neurosci 220 677 PMID: 24623156
Schuster et al (2015) Ligand requirements for involvement of PKCη in synergistic analgesic interactions between spinal μ and δ opioid receptors. Transl Oncol 172 642 PMID: 24827408
Butelman et al (2010) The discriminative effects of the kappa-opioid hallucinogen salvinorin A in nonhuman primates: dissociation from classic hallucinogen effects. Psychopharmacology (Berl) 210 253 PMID: 20084367
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