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Sonidegib

Cat. No. 7826 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent Smoothened receptor antagonist
化学名： rel-N-[6-[(2R,6S)-2,6-Dimethyl-4-morpholinyl]-3-pyridinyl]-2-methyl-4'-(trifluoromethoxy)[1,1'-biphenyl]-3-carboxamide
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Sonidegib

Sonidegib is a potent Smoothened (Smo) receptor antagonist (IC50 values are 1.3 nM and 2.5 nM at mouse and human receptors, respectively). Inhibits growth of a variety of tumor types including basal cell carcinoma, small cell lung cancer and medulloblastoma. Sonidegib inhibits Hh pathway in CD34+ chronic myeloid leukemia cells; it reduces both the number of cells and self-renewal ability. Brain penetrant and orally bioavailable.

技术数据 for Sonidegib

分子量 485.51
公式 C26H26F3N3O3
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 956697-53-3
InChI Key VZZJRYRQSPEMTK-CALCHBBNSA-N
Smiles CC1=C(C2=CC=C(C=C2)OC(F)(F)F)C=CC=C1C(NC3=CN=C(N4C[C@H](O[C@H](C4)C)C)C=C3)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Sonidegib

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 48.55 100

制备储备液 for Sonidegib

以下数据基于产品分子量 485.51。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.06 mL 10.3 mL 20.6 mL
5 mM 0.41 mL 2.06 mL 4.12 mL
10 mM 0.21 mL 1.03 mL 2.06 mL
50 mM 0.04 mL 0.21 mL 0.41 mL

Molarity Calculator

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参考文献 for Sonidegib

参考文献是支持产品生物活性的出版物。

Pan et al (2010) Discovery of NVP-LDE225, a potent and selective smoothened antagonist. ACS Med.Chem.Lett. 1 130 PMID: 24900187

Irvine et al (2016) Deregulated hedgehog pathway signaling is inhibited by the smoothened antagonist LDE225 (Sonidegib) in chronic phase chronic myeloid leukaemia. Sci.Rep. 6 25476 PMID: 27157927

If you know of a relevant reference for Sonidegib, please let us know.

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关键词: Sonidegib, Sonidegib supplier, smoothened, smo, antagonist, tumor, growth, inhibitors, lung, medulloblastoma, SCLC, BCC, basal, cell, carcinoma, Hh, hedgehog, Smoothened, Receptors, 7826, Tocris Bioscience

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Stem Cell Research Product Guide

Stem Cell Research Product Guide

This product guide provides a background to the use of small molecules in stem cell research and lists over 200 products for use in:

  • Self-renewal and Maintenance
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