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Spadin

Cat. No. 5594 1 次引用 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent K2P2.1 (TREK-1) channel blocker
纯度： ≥95% (HPLC)
说明书
引用文献 (1)
评论 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Spadin

Spadin is a potent TREK-1 channel blocker (IC50 = 71 nM). Enhances dorsal raphe nucleus 5-HT neurotransmission in mice. Induces hippocampal CREB activation and neurogenesis in adult mice. Exhibits antidepressant effects in mouse models of depression. Brain penetrant.

技术数据 for Spadin

分子量 2012.34
公式 C96H142N26O22
序列 YAPLPRWSGPIGVSWGLR
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 1270083-24-3
PubChem ID 91826106
InChI Key WMSPWLIEKXALQP-WSSJNERPSA-N
Smiles [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CO)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Spadin

溶解性 Soluble to 2 mg/ml in water

产品说明书 for Spadin

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for Spadin

参考文献是支持产品生物活性的出版物。

Mazella et al (2010) Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design. PLoS Biol. 8 e1000355 PMID: 20405001

Borsotto et al (2015) Targeting two-pore domain K(+) channels TREK-1 and TASK-3 for the treatment of depression: a new therapeutic concept. Br.J.Pharmacol. 172 771 PMID: 25263033

If you know of a relevant reference for Spadin, please let us know.

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关键词: Spadin, Spadin supplier, potent, TREK-1, channels, inhibits, inhibitors, depression, antidepressants, CREB, neurotensin, receptors, NTSR3, gp95, sortilin, K2P, KCNK2, Two-P, Potassium, Channels, 5594, Tocris Bioscience

1 篇 Spadin 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Spadin 的部分引用包括：

Fernandez-Fernandez et al (2018) Activation of TREK currents by riluzole in three subgroups of cultured mouse nodose ganglion neurons. PLoS One 13 e0199282 PMID: 29928032

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Spadin 的评论

平均评分: 5 (Based on 1 Review.)

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A very potent K2p channel blocker.
By Anonymous on 01/31/2019
分析类型： In Vitro
种属： Human

A very potent K2p channel blocker which was used to figure out the blocking activity as concentration of the blocker molecule increased. Spadin is a great antagonist molecule which shows channel blocking properties which is concentration dependent.

review image