Spexin

Cat. No. 6090 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent GAL_2/3 agonist; exhibits anxiolytic effects in vivo

别名： NPQ,Neuropeptide Q

纯度： ≥95% (HPLC)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Spexin

Spexin is a potent galanin receptor 2/3 (GAL₂/GAL₃) agonist (EC₅₀ values are 45.7 and 112.2 nM, respectively). Exhibits no significant activity at galanin receptor 1. Endogenous satiety-inducing peptide; inhibits long chain fatty acid uptake by adipocytes and decreases food consumption in diet-induced obese mice and rats. Attenuates LH secretion in goldfish. Exhibits anxiolytic effects in vivo.

技术数据 for Spexin

分子量	1619.9
公式	C₇₄H₁₁₄N₂₀O₁₉S
序列	NWTPQAMLYLKGAQ (Modifications: Gln-14 = C-terminal amide)
储存	Store at -20°C
纯度	≥95% (HPLC)
CAS Number	1370290-58-6
PubChem ID	122705996
InChI Key	ZZDZBDJTNIOJMF-TWMPYRTRSA-N
Smiles	[H]N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(N)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

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溶解性数据 for Spexin

溶解性	Soluble to 1 mg/ml in water

产品说明书 for Spexin

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Spexin

参考文献是支持产品生物活性的出版物。

Walewski et al (2014) Spexin is a novel human peptide that reduces adipocyte uptake of long chain fatty acids and causes weight loss in rodents with diet-induced obesity Obesity (Silver Spring) 22 1643 PMID: 24550067

Reyes-Alcaraz et al (2016) Development of spexin-based human galanin receptor type II-specific agonists with increased stability in serum and anxiolytic effect in mice. Sci.Rep. 6 21453 PMID: 26907960

Kim et al (2014) Coevolution of the spexin/galanin/kisspeptin family: Spexin activates galanin receptor type II and III. Endocrinology 155 1864 PMID: 24517231

If you know of a relevant reference for Spexin, please let us know.

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关键词: Spexin, Spexin supplier, Potent, galanin, receptors, 2, 3, agonists, agonism, GAL, endogenous, satiety, inducing, peptides, anxiolytic, anxiety, diabetes, obesity, NPQ, Neuropeptide, Q, Galanin, Receptors, 6090, Tocris Bioscience

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Peptides Involved in Appetite Modulation Scientific Review

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