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Submit ReviewSpironolactone
说明： Mineralocorticoid receptor antagonist
别名： SC 9420,Aldactone
化学名： (7α,17α)-7-(Acetylthio)-17-hydroxy-3-oxopregn-4-ene-21-carboxylic acid γ-lactone
纯度： ≥98% (HPLC)
生物活性 for Spironolactone
Spironolactone is a competitive mineralocorticoid (aldosterone) receptor antagonist that exhibits antihypertensive activity in vivo. Also displays antiandrogen activity and inhibits steroid hormone biosynthesis.
化合物库 for Spironolactone
Spironolactone is also offered as part of the Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。
技术数据 for Spironolactone
| 分子量 | 416.57 |
| 公式 | C24H32O4S |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 52-01-7 |
| PubChem ID | 5833 |
| InChI Key | LXMSZDCAJNLERA-ZHYRCANASA-N |
| Smiles | O=C1CC[C@@]2(C)C(C[C@@H](SC(C)=O)[C@]3([H])[C@@]([H])2CC[C@@]4(C)[C@]([H])3CC[C@@]54OC(CC5)=O)=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Spironolactone
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 41.66 | 100 | |
| ethanol | 20.83 | 50 |
制备储备液 for Spironolactone
以下数据基于产品分子量 416.57。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.4 mL | 12 mL | 24.01 mL |
| 5 mM | 0.48 mL | 2.4 mL | 4.8 mL |
| 10 mM | 0.24 mL | 1.2 mL | 2.4 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
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产品说明书 for Spironolactone
参考文献 for Spironolactone
参考文献是支持产品生物活性的出版物。
Delyani et al (2000) Mineralocorticoid receptor antagonists: the evolution of utility and pharmacology. Kidney Int. 57 1408 PMID: 10760075
Struthers et al (2008) A comparison of the aldosterone-blocking agents eplernone and spironola. Clin.Cardiol. 31 153 PMID: 18404673
Ye et al (2009) Contrasting effects of epler. and spironola. on adrenal cell steroidogenesis. Horm.Metab.Res. 41 35 PMID: 18819053
If you know of a relevant reference for Spironolactone, please let us know.
按产品操作查看相关产品
关键词: Spironolactone, Spironolactone supplier, Anti-Androgen, AntiAndrogen, inhibits, inhibitors, steroid, hormone, biosynthesis, MR, antagonists, Mineralocorticoid, receptor, Dihydrotestosterone, Receptors, Androgen, Aldosterone, SC9420, SC, 9420, Aldactone, Receptor, 2968, Tocris Bioscience
⚠ WARNING: This product can expose you to chemicals including Spironolactone, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov
3 篇 Spironolactone 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Spironolactone 的部分引用包括：
Pinheiro et al (2016) Hierarchical glucocorticoid-endocannabinoid interplay regulates the activation of the nucleus accumbens by insulin. Brain Res Bull 124 222 PMID: 27208730
Liu et al (2014) Chronic stress impairs GABAergic control of amygdala through suppressing the tonic GABAA receptor currents. Mol Brain 7 32 PMID: 24758222
Thai et al (2013) Effects of acute restraint stress on set-shifting and reversal learning in male rats. Cogn Affect Behav Neurosci 13 164 PMID: 23055093
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