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SPRi 3

Cat. No. 6597 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent sepiapterin reductase (SPR) inhibitor; attenuates proliferation of CD4+ T cells
化学名： N-[2-(5-Hydroxy-2-methyl-1H-indol-3-yl)ethyl]-2-methoxyacetamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for SPRi 3

SPRi 3 is a potent sepiapterin reductase (SPR) inhibitor (IC50 = 53 - 74 nM for human SPR). Inhibits BH4 synthesis pathway and attenuates proliferation in naive CD4+ T cells. Suppresses proliferation of human effector CD4+ T cells following stimulation. Reduces SPR activity in mouse primary cultures of sensory neurons (IC50 = 450 nM). Ameliorates colitis, suppressing the intestinal infiltration of T cells and other immune cells in vivo. Also reduces immune-cell infiltration into mouse lungs. Reduces neuropathic and inflammatory pain in mouse models.

许可信息

Sold under license from the Children's Medical Center Corporation.

化合物库 for SPRi 3

SPRi 3 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for SPRi 3

分子量 262.3
公式 C14H18N2O3
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1292285-54-1
PubChem ID 52911386
InChI Key YBXBWBBVLXZQBJ-UHFFFAOYSA-N
Smiles COCC(NCCC1=C(NC2=CC=C(C=C12)O)C)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SPRi 3

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 26.23 100
ethanol 26.23 100

制备储备液 for SPRi 3

以下数据基于产品分子量 262.3。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.81 mL 19.06 mL 38.12 mL
5 mM 0.76 mL 3.81 mL 7.62 mL
10 mM 0.38 mL 1.91 mL 3.81 mL
50 mM 0.08 mL 0.38 mL 0.76 mL

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产品说明书 for SPRi 3

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for SPRi 3

参考文献是支持产品生物活性的出版物。

Haruki et al (2016) Tetrahydrobiopterin biosynthesis as a potential target of the kynurenine pathway metabolite xanthurenic acid. J.Biol.Chem. 291 652 PMID: 26565027

Latremoliere et al (2015) Reduction of neuropathic and inflammatory pain through inhibition of the tetrahydrobiopterin pathway. Neuron 86 1393 PMID: 26087165

Cronin et al (2018) The metabolite BH4 controls T cell proliferation in autoimmunity and cancer. Nature 563 564 PMID: 30405245

If you know of a relevant reference for SPRi 3, please let us know.

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关键词: SPRi 3, SPRi 3 supplier, SPRi3, sepiapterin, reductase, SPR, inhibitors, inhibits, tetrahydrobiopterin, pathway, BH4, Tcells, T, cells, CD4+, Other, Reductase, 6597, Tocris Bioscience

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