SPT Imidazopyridine 1

Cat. No. 6055 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent serine palmitoyl transferase inhibitor

化学名： 4-[6-(1-Oxoheptyl)imidazo[1,2-a]pyridin-8-yl]benzeneacetic acid

纯度： ≥98%

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for SPT Imidazopyridine 1

SPT Imidazopyridine 1 is a potent serine palmitoyl transferase (SPT) inhibitor (IC₅₀ = 5 nM). Dose-dependently inhibits incorporation of ¹⁴C-serine into ceramide. Reduces plasma ceramide levels in vivo. Also increases plasma HDL and reduces vLDL cholesterol levels in rats.

技术数据 for SPT Imidazopyridine 1

分子量	364.44
公式	C₂₂H₂₄N₂O₃
储存	Store at +4°C
纯度	≥98%
CAS Number	1933533-18-6
PubChem ID	131954583
InChI Key	MMYRYMMKMUTPBB-UHFFFAOYSA-N
Smiles	CCCCCCC(C1=CN2C=CN=C2C(C3=CC=C(C=C3)CC(O)=O)=C1)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SPT Imidazopyridine 1

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	36.44	100

制备储备液 for SPT Imidazopyridine 1

以下数据基于产品分子量 364.44。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.74 mL	13.72 mL	27.44 mL
5 mM	0.55 mL	2.74 mL	5.49 mL
10 mM	0.27 mL	1.37 mL	2.74 mL
50 mM	0.05 mL	0.27 mL	0.55 mL

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产品说明书 for SPT Imidazopyridine 1

分析证书/产品说明书

化学品安全技术说明书

参考文献 for SPT Imidazopyridine 1

参考文献是支持产品生物活性的出版物。

Genin et al (2016) Imidazopyridine and pyrazolopiperidine derivatives as novel inhibitors of serine palmitoyl transferase. J.Med.Chem. 59 5904 PMID: 27213958

If you know of a relevant reference for SPT Imidazopyridine 1, please let us know.

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关键词: SPT Imidazopyridine 1, SPT Imidazopyridine 1 supplier, serine, palmitoyl, transferase, SPT, inhibitors, inhibits, potent, ceramides, hypercholesterolemia, sphingolipids, palmitoyltransferase, Other, Transferases, 6055, Tocris Bioscience

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