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SR 0987

Cat. No. 5868 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： T cell-specific RORγ (RORγt) agonist
化学名： 2-Chloro-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]benzamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for SR 0987

SR 0987 is a T cell-specific RORγ (RORγt) agonist (EC50 = 800 nM in a gene reporter assay). Induces IL-17 expression and decreases PD-1 expression in T cells in vitro.

化合物库 for SR 0987

SR 0987 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for SR 0987

分子量 397.7
公式 C16H10ClF6NO2
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 303126-97-8
PubChem ID 2323435
InChI Key IZVBONMVWLTLNT-UHFFFAOYSA-N
Smiles OC(C(F)(F)F)(C(F)(F)F)C1=CC=C(C=C1)NC(C2=C(C=CC=C2)Cl)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SR 0987

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 39.77 100
ethanol 39.77 100

制备储备液 for SR 0987

以下数据基于产品分子量 397.7。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.51 mL 12.57 mL 25.14 mL
5 mM 0.5 mL 2.51 mL 5.03 mL
10 mM 0.25 mL 1.26 mL 2.51 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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参考文献 for SR 0987

参考文献是支持产品生物活性的出版物。

Chang et al (2016) Synthetic RORγt agonists enhance protective immunity. ACS Chem.Biol. 11 1012 PMID: 26785144

If you know of a relevant reference for SR 0987, please let us know.

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