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SR 1078

Cat. No. 4874 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： RORα/γ agonist
化学名： N-[4-[2,2,2-Trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4-(trifluoromethyl)benzamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for SR 1078

SR 1078 is an agonist of retinoic acid receptor-related orphan receptors (ROR) RORα/γ. Increases transcription of RORα target genes; thought to increase p53 stability.

许可信息

Sold under license from The Scripps Research Institute.

化合物库 for SR 1078

SR 1078 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for SR 1078

分子量 431.25
公式 C17H10F9NO2
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 1246525-60-9
PubChem ID 17980288
InChI Key DUXWIYXHHGNUJU-UHFFFAOYSA-N
Smiles OC(C(F)(F)F)(C(F)(F)F)C(C=C1)=CC=C1NC(C2=CC=C(C(F)(F)F)C=C2)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SR 1078

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 43.12 100
ethanol 43.12 100

制备储备液 for SR 1078

以下数据基于产品分子量 431.25。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.32 mL 11.59 mL 23.19 mL
5 mM 0.46 mL 2.32 mL 4.64 mL
10 mM 0.23 mL 1.16 mL 2.32 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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参考文献 for SR 1078

参考文献是支持产品生物活性的出版物。

Wang et al (2010) Identification of a synthetic agonist for the orphan nuclear receptors RORα and RORγ, SR1078. ACS Chem.Biol. 5 1029 PMID: 20735016

Wang et al (2012) Regulation of p53 stability and apoptosis by a ROR agonist. PLoS One 7 e34921 PMID: 22509368

If you know of a relevant reference for SR 1078, please let us know.

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关键词: SR 1078, SR 1078 supplier, SR1078, retinoic, acid, receptor-related, orphan, receptor, RORα, RORalpha, RORa, RORgamma, RORγ, RORg, agonists, Retinoic, Acid-related, Orphan, Receptors, 4874, Tocris Bioscience

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