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Submit ReviewSR 12813
说明： Pregnane X receptor agonist
化学名： [[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]ethenylidene]bis-phosphonic acid tetraethyl ester
纯度： ≥99% (HPLC)
生物活性 for SR 12813
SR 12813 is a pregnane X receptor (PXR) agonist (EC50 values are 200 and 700 nM for human and rabbit PXR respectively). Activates the farnesoid X receptor (FXR) at μM concentrations. Displays hypocholesterolemic activity via enhanced degradation of HMG-CoA reductase.
技术数据 for SR 12813
| 分子量 | 504.53 |
| 公式 | C24H42O7P2 |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 126411-39-0 |
| PubChem ID | 446313 |
| InChI Key | YQLJDECYQDRSBI-UHFFFAOYSA-N |
| Smiles | OC1=C(C(C)(C)C)C=C(/C=C(P(OCC)(OCC)=O)/P(OCC)(OCC)=O)C=C1C(C)(C)C |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for SR 12813
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 50.45 | 100 | |
| ethanol | 50.45 | 100 |
制备储备液 for SR 12813
以下数据基于产品分子量 504.53。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.98 mL | 9.91 mL | 19.82 mL |
| 5 mM | 0.4 mL | 1.98 mL | 3.96 mL |
| 10 mM | 0.2 mL | 0.99 mL | 1.98 mL |
| 50 mM | 0.04 mL | 0.2 mL | 0.4 mL |
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产品说明书 for SR 12813
参考文献 for SR 12813
参考文献是支持产品生物活性的出版物。
Berkhout et al (1996) The novel cholesterol-lowering drug SR-12813 inhibits cholesterol synthesis via an increased degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase J.Biol.Chem. 271 14376 PMID: 8662919
Lemaire et al (2007) Discovery of a highly active ligand of human pregnane X receptor: a case study from pharmacophore modeling and virtual screening to "in vivo" biological activity. Mol.Pharmacol. 72 572 PMID: 17573484
Jones et al (2000) The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution. Mol.Pharmacol. 14 27
If you know of a relevant reference for SR 12813, please let us know.
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关键词: SR 12813, SR 12813 supplier, Pregnane, X, receptor, PXR, agonists, Nuclear, Receptors, SR12813, HMG-CoA, Reductase, Receptor, 2969, Tocris Bioscience
1 篇 SR 12813 的引用文献
引用文献是使用了 Tocris 产品的出版物。 SR 12813 的部分引用包括：
Delfosse et al (2015) Synergistic activation of human pregnane X receptor by binary cocktails of pharmaceutical and environmental compounds. Nat Commun 6 8089 PMID: 26333997
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