Pregnane X Receptors
Pregnane X receptors (PXRs) are nuclear receptors that regulate the expression of CYP3A genes, generating key enzymes involved in xenobiotic metabolism. PXRs also help regulate the induction of P-gp. PXRs are highly expressed in the liver, small intestine and colon.
Pregnane X Receptor Agonists |
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|---|---|
| Cat. No. | 产品名称/活性 |
| 4245 | Meclizine dihydrochloride |
| Human pregnane X receptor agonist; H1 antagonist | |
| 2969 | SR 12813 |
| Pregnane X receptor agonist | |
Pregnane X receptors (PXRs) are nuclear receptors that regulate the expression of CYP3A genes, thus generating key enzymes involved in xenobiotic metabolism. PXRs also help regulate the induction of P-gp. PXRs are highly expressed in the liver, small intestine and colon.
Numerous ligands activate PXRs, including a range of xenobiotics such as dexamethasone and nifedipine, and naturally occurring steroids. PXR forms a non-permissive heterodimer with RXR receptors in order to bind the promoter and enhancer of the CYP3A4 gene.
External sources of pharmacological information for Pregnane X Receptors :
Literature for Pregnane X Receptors
Tocris offers the following scientific literature for Pregnane X Receptors to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Retinoid Receptors Scientific Review
Written by Alexander Moise, this review summarizes the nature of retinoid receptors, their isotype and isoform variants and modulation of retinoid signaling. Compounds available from Tocris are listed.
Our Retinoid Receptors review gives a summary of retinoic acid and retinoid X receptor pharmacology, and the modulation of retinoid signaling.
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