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SR 13800

Cat. No. 5431 4 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent MCT1 inhibitor
化学名： 2,6-Dihydro-7-[(3-hydroxypropyl)thio]-2-methyl-4-(2-methylpropyl)-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyridazin-1one
纯度： ≥98% (HPLC)
说明书
引用文献 (4)
评论
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for SR 13800

SR 13800 is a potent MCT1 inhibitor (IC50 = 0.5 nM); blocks proliferation of Raji lymphoma cells in vitro. Also inhibits lactate uptake in breast cancer cells in vitro.

技术数据 for SR 13800

分子量 435.58
公式 C25H29N3O2S
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 227321-12-2
PubChem ID 5282542
InChI Key VDAVMXLEMHVXOG-UHFFFAOYSA-N
Smiles O=C1N(C)N=C(CC(C)C)C2=CN(CC3=C(C=CC=C4)C4=CC=C3)C(SCCCO)=C12

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SR 13800

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 43.56 100
ethanol 8.71 20

制备储备液 for SR 13800

以下数据基于产品分子量 435.58。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.3 mL 11.48 mL 22.96 mL
5 mM 0.46 mL 2.3 mL 4.59 mL
10 mM 0.23 mL 1.15 mL 2.3 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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参考文献 for SR 13800

参考文献是支持产品生物活性的出版物。

Murray et al (2005) Monocarboxylate transporter MCT1 is a target for immunosuppression. Nat.Chem.Biol. 1 371 PMID: 16370372

Wang et al (2014) Synthesis and structure-activity relationships of pteridine dione and trione monocarboxylate transporter 1 inhibitors. J.Med.Chem. 57 7317 PMID: 25068893

If you know of a relevant reference for SR 13800, please let us know.

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关键词: SR 13800, SR 13800 supplier, SR13800, potent, MCT1, inhibitors, inhibits, lactate, uptake, anticancer, antitumour, antitumor, SLC16A1, monocarboxylate, transporters, Monocarboxylate, Transporters, 5431, Tocris Bioscience

4 篇 SR 13800 的引用文献

引用文献是使用了 Tocris 产品的出版物。 SR 13800 的部分引用包括：

Joselyn et al (2022) A Heme-Binding Transcription Factor BACH1 Regulates Lactate Catabolism Suggesting a Combined Therapy for Triple-Negative Breast Cancer. Cells 11 PMID: 35406740

Maacha et al (2018) AXL Mediates Esophageal Adenocarcinoma Cell Invasion through Regulation of Extracellular Acidification and Lysosome Trafficking. Neoplasia 20 1008 PMID: 30189359

Liu et al (2017) The Glia-Neuron Lactate Shuttle and Elevated ROS Promote Lipid Synthesis in Neurons and Lipid Droplet Accumulation in Glia via APOE/D. Cell Metab 26 719 PMID: 28965825

Alejandra et al (2023) Evaluation of Photobiomodulation and Boldine as Alternative Treatment Options in Two Diabetic Retinopathy Models. Int J Mol Sci 24 PMID: 37175628

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