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SR 202

Cat. No. 2022 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective PPARγ antagonist; antidiabetic and antiobesity agent
别名： Mifobate
化学名： (4-Chlorophenyl)(dimethoxyphosphinyl)methyl phosphoric acid dimethyl ester
纯度： ≥99% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for SR 202

SR 202 is a selective PPARγ antagonist; antidiabetic and antiobesity agent. Attenuates troglitazone-induced PPARγ transcriptional activity (IC50 = 140 μM) without affecting ligand-stimulated PPARα, PPARβ or FXR transcriptional activity. Inhibits PPARγ-dependent adipocyte differentiation and growth in vitro and in vivo. Improves insulin sensitivity in diabetic ob/ob mice and increases HDL levels in rats in vivo.

技术数据 for SR 202

分子量 358.65
公式 C11H17ClO7P2
储存 Desiccate at RT
纯度 ≥99% (HPLC)
CAS Number 76541-72-5
PubChem ID 60910
InChI Key VQHUQHAPWMNBLP-UHFFFAOYSA-N
Smiles COP(=O)(OC)OC(C1=CC=C(Cl)C=C1)P(=O)(OC)OC

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SR 202

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 35.87 100

制备储备液 for SR 202

以下数据基于产品分子量 358.65。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.79 mL 13.94 mL 27.88 mL
5 mM 0.56 mL 2.79 mL 5.58 mL
10 mM 0.28 mL 1.39 mL 2.79 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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参考文献 for SR 202

参考文献是支持产品生物活性的出版物。

Nguyen et al (1987) gem-Diphosphonate and gem-phosphonate-phosphate compounds with specific high density lipoprotein inducing activity. J.Med.Chem. 30 1426 PMID: 3612689

Rieusset et al (2002) A new selective peroxisome proliferator-activated receptor γ antagonist with antiobesity and antidiabetic activity. Mol.Endocrinol. 16 2628 PMID: 12403851

Doggrell (2003) Do peroxisome proliferation receptor-γ antagonists have clinical potential as combined antiobesity and antidiabetic drugs? Expert.Opin.Invest.Drugs 12 713

If you know of a relevant reference for SR 202, please let us know.

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关键词: SR 202, SR 202 supplier, Selective, PPARγ, PPARgamma, antagonists, antidiabetic, antiobesity, agent, Peroxisome, Proliferator-activating, Receptors, SR202, Mifobate, 2022, Tocris Bioscience

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