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SR 2211

Cat. No. 4869 3 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective RORγ inverse agonist
化学名： 2-Fluoro-4'-[[4-(4-pyridinylmethyl)-1-piperazinyl]methyl]-a,a-bis(trifluoromethyl)-[1,1'-biphenyl]-4-methanol
纯度： ≥98% (HPLC)
说明书
引用文献 (3)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for SR 2211

SR 2211 is a selective inverse agonist of retinoic acid receptor-related orphan receptor γ (RORγ) (Ki = 105 nM; IC50 ~320 nM). Exhibits weak activity at liver X receptor α (LXRα); does not affect the transcriptional activity of farnesoid X receptors (FXR), and has no impact on the transcriptional activity of RORα.

许可信息

Sold under license from The Scripps Research Institute.

化合物库 for SR 2211

SR 2211 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for SR 2211

分子量 527.48
公式 C26H24F7N3O
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1359164-11-6
PubChem ID 51035449
InChI Key KVHKWAZUPPBMLL-UHFFFAOYSA-N
Smiles FC(C=C(C(O)(C(F)(F)F)C(F)(F)F)C=C4)=C4C(C=C3)=CC=C3CN(CC2)CCN2CC1=CC=NC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SR 2211

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 52.75 100

制备储备液 for SR 2211

以下数据基于产品分子量 527.48。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.9 mL 9.48 mL 18.96 mL
5 mM 0.38 mL 1.9 mL 3.79 mL
10 mM 0.19 mL 0.95 mL 1.9 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

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产品说明书 for SR 2211

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for SR 2211

参考文献是支持产品生物活性的出版物。

Kumar et al (2012) Identification of SR2211: a potent synthetic RORγ-selective modulator. ACS Chem.Biol. 7 672 PMID: 22292739

If you know of a relevant reference for SR 2211, please let us know.

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关键词: SR 2211, SR 2211 supplier, SR2211, inverse, agonists, retinoic, acid, receptor-related, orphan, receptor, RORg, RORgamma, RORγ, selective, Retinoic, Acid-related, Orphan, Receptors, 4869, Tocris Bioscience

3 篇 SR 2211 的引用文献

引用文献是使用了 Tocris 产品的出版物。 SR 2211 的部分引用包括：

Brian T et al (2021) Vitamin D Inhibits IL-22 Production Through a Repressive Vitamin D Response Element in the il22 Promoter. Front Immunol 12 715059 PMID: 34408754

Hong-Wu et al (2021) Targeting Feedforward Loops Formed by Nuclear Receptor RORγ and Kinase PBK in mCRPC with Hyperactive AR Signaling. Cancers (Basel) 13 PMID: 33916325

Peter D et al (2019) A Multiscale Map of the Stem Cell State in Pancreatic Adenocarcinoma. Cell 177 572-586.e22 PMID: 30955884

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