SR 2640 hydrochloride

Name: SR 2640 hydrochloride
Brand: Tocris Bioscience
SKU: 1804

Cat. No. 1804 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

1804 has been discontinued.

View all Leukotriene and Related Receptors products.

说明： Potent, selective LTD₄ /LTE₄ receptor antagonist

化学名： 2-[[3-(2-Quinolinylmethoxy)phenyl]amino]benzoic acid hydrochloride

纯度： ≥99% (HPLC)

说明书

引用文献 (1)

生物活性技术数据说明书参考文献

生物活性 for SR 2640 hydrochloride

SR 2640 hydrochloride is a potent and selective competitive leukotriene D₄ and E₄ receptor antagonist. Inhibits LTD₄- but not histamine-induced guinea pig ileum and trachea contraction (pA₂ = 8.7). Also inhibits LTD₄-attenuation of human PMN chemotaxis. Orally active in vivo.

技术数据 for SR 2640 hydrochloride

分子量	406.87
公式	C₂₃H₁₈N₂O₃.HCl
储存	Desiccate at RT
纯度	≥99% (HPLC)
CAS Number	146662-42-2
PubChem ID	45073453
InChI Key	KDSYWFCTUKABKE-UHFFFAOYSA-N
Smiles	Cl.OC(=O)C1=CC=CC=C1NC1=CC(OCC2=CC=C3C=CC=CC3=N2)=CC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for SR 2640 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for SR 2640 hydrochloride

参考文献是支持产品生物活性的出版物。

Ahnfelt-Ronne et al (1988) A novel leukotriene D₄/E₄ antagonist, SR2640 (2-[3-(2-quinolylmethoxy)phenylamino]benzoic acid). Eur.J.Pharmacol. 155 117 PMID: 2854067

Bouchelouche et al (1990) LTD₄ increases cytosolic free calcium and inositol phosphates in human neutrophils: inhibition by the novel LTD₄ receptor antagonist, SR2640, and possible relation to modulation of chemotaxis. Agents Actions 29 299 PMID: 2160189

Thomsen and Ahnfelt-Ronne (1989) Inhibition by the LTD₄ antagonist, SR2640, of effects of LTD4 on canine polymorphonuclear leukocyte functions. Biochem.Pharmacol. 38 2291 PMID: 2546563

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Leukotriene and Related Receptors

关键词: SR 2640 hydrochloride, SR 2640 hydrochloride supplier, Potent, selective, LTD4, /LTE4, receptors, antagonists, leukotrienes, eicosanoids, SR2640, hydrochloride, Leukotriene, and, Related, Receptors, 1804, Tocris Bioscience

1 篇 SR 2640 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 SR 2640 hydrochloride 的部分引用包括：

Wright et al (2019) Pranlukast is a novel small molecule activator of the two-pore domain potassium channel TREK2. Biochem Biophys Res Commun 520 35 PMID: 31564414