SR 58611A hydrochloride

Cat. No. 3986 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： β3 agonist; displays anxiolytic and antidepressant effects

化学名： [[(7S)-7-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-5,6,7,8-tetrahydro-2-naphthalenyl]ox]yacetic acid ethyl ester hydrochloride

纯度： ≥98% (HPLC)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for SR 58611A hydrochloride

SR 58611A hydrochloride is a selective β3-adrenergic receptor agonist. Displays both anxiolytic and antidepressant effects in rodent models. Orally active and brain penetrant.

化合物库 for SR 58611A hydrochloride

SR 58611A hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for SR 58611A hydrochloride

分子量	440.36
公式	C₂₂H₂₆ClNO₄.HCl
储存	Desiccate at RT
纯度	≥98% (HPLC)
CAS Number	121524-09-2
PubChem ID	121888
InChI Key	NQIZCDQCNYCVAS-RQBPZYBGSA-N
Smiles	O=C(OCC)COC1=CC=C(CC[C@H](NC[C@H](O)C3=CC(Cl)=CC=C3)C2)C2=C1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SR 58611A hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	44.04	100

制备储备液 for SR 58611A hydrochloride

以下数据基于产品分子量 440.36。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.27 mL	11.35 mL	22.71 mL
5 mM	0.45 mL	2.27 mL	4.54 mL
10 mM	0.23 mL	1.14 mL	2.27 mL
50 mM	0.05 mL	0.23 mL	0.45 mL

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产品说明书 for SR 58611A hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for SR 58611A hydrochloride

参考文献是支持产品生物活性的出版物。

Consoli et al (2007) Behavioral effects of the β3 adrenoceptor agonist SR58611A: is it the putative prototype of a new class of antidepressant/anxiolytic drugs? Eur.J.Pharmacol 573 139 PMID: 17669397

Claustre et al (2008) Effects of the β3-adrenoceptor (Adrb3) agonist SR58611A (amibegron) on serotonergic and noradrenergic transmission in the rodent: relevance to its antidepressant/anxiolytic-like profile. Neuroscience 156 353 PMID: 18691638

Stemmelin et al (2008) Stimulation of the β₃-adrenoceptor as a novel treatment strategy for anxiety and depressive disorders. Neuropsychopharmacology 33 574 PMID: 17460614

Tamburella et al (2010) The beta(3) adrenoceptor agonist, amibegron (SR58611A) counteracts stress-induced behavioral and neurochemical changes. Eur.Neuropsychopharmacol. 20 704 PMID: 20537869

If you know of a relevant reference for SR 58611A hydrochloride, please let us know.

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