SR 59230A hydrochloride

Cat. No. 1511 14 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent and selective β₃ antagonist

化学名： 1-(2-Ethylphenoxy)-3-[[(1S)-1,2,3,4-tetrahydro-1-naphthalenyl]amino]-(2S)-2-propanol hydrochloride

纯度： ≥98% (HPLC)

引用文献 (14)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for SR 59230A hydrochloride

SR 59230A hydrochloride is a potent and selective β₃ adrenoceptor antagonist (IC₅₀ values are 40, 408 and 648 nM for β₃, β₁ and β₂ receptors respectively). Orally active in vivo.

化合物库 for SR 59230A hydrochloride

SR 59230A hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for SR 59230A hydrochloride

分子量	361.91
公式	C₂₁H₂₇NO₂.HCl
储存	Store at RT
纯度	≥98% (HPLC)
CAS Number	1135278-41-9
PubChem ID	24978529
InChI Key	SHUCXUIOEAAJJL-MKSBGGEFSA-N
Smiles	O[C@@H](CN[C@H]2CCCC3=C2C=CC=C3)COC1=C(CC)C=CC=C1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SR 59230A hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	3.62	10
	DMSO	36.19	100

制备储备液 for SR 59230A hydrochloride

以下数据基于产品分子量 361.91。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.76 mL	13.82 mL	27.63 mL
5 mM	0.55 mL	2.76 mL	5.53 mL
10 mM	0.28 mL	1.38 mL	2.76 mL
50 mM	0.06 mL	0.28 mL	0.55 mL

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产品说明书 for SR 59230A hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for SR 59230A hydrochloride

参考文献是支持产品生物活性的出版物。

Manara et al (1996) Functional identification of rat atypical β-adrenoceptors by the first β₃-selective antagonists, aryloxypropanolaminotetralins. Br.J.Pharmacol. 117 435 PMID: 8821531

Mizuno et al (2002) Stimulation of β₃-adrenoceptors causes phosphorylation of p38 mitogen-activated protein kinase via a stimulatory G protein-dependent pathway in 3T3-L1 adipocytes. Br.J.Pharmacol. 135 951 PMID: 11861323

Manara et al (1995) Aryloxypropanolaminotetralins are the first selective antagonists for atypical (β₃) β-adrenoceptors. Pharmacol.Comm. 6 253

If you know of a relevant reference for SR 59230A hydrochloride, please let us know.

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关键词: SR 59230A hydrochloride, SR 59230A hydrochloride supplier, Potent, selective, β3-adrenoceptor, b3-adrenoceptor, β3-adrenergic, b3-adrenergic, antagonists, Receptors, SR59230A, hydrochloride, Adrenergic, Beta-3, 1511, Tocris Bioscience

14 篇 SR 59230A hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 SR 59230A hydrochloride 的部分引用包括：

Lavine (2017) β2-Adrenergic Receptor Antagonism Attenuates CNV Through Inhibition of VEGF and IL-6 Expression. Invest Ophthalmol Vis Sci 58 299 PMID: 28114591

Martínez-Sánchez et al (2017) Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance. Cell Metab 26 212 PMID: 28683288

Sun et al (2015) Adrenergic DNA damage of embryonic pluripotent cells via β2 receptor signalling. J Neuroimmunol 5 15950 PMID: 26516061

Sood et al (2010) Adrenergic modulation of focal adhesion kinase protects human ovarian cancer cells from anoikis. J Clin Invest 120 1515 PMID: 20389021

Enriori et al (2011) Leptin action in the dorsomedial hypothalamus increases sympathetic tone to brown adipose tissue in spite of systemic leptin resistance. Mamm Genome 31 12189 PMID: 21865462

González-García et al (2018) E2 Regulates Energy Balance by Ameliorating Hypothalamic Ceramide-Induced ER Stress. Cell Rep 25 413 PMID: 30304681

Brosnahan et al (2013) NE potentiates proinflammatory responses of human vaginal epithelial cells. J Neurosci 259 42583 PMID: 23571017

Armaiz-Pena et al (2015) Adrenergic regulation of monocyte chemotactic protein 1 leads to enhanced macrophage recruitment and ovarian carcinoma growth. Oncotarget 6 4266 PMID: 25738355

Rankovic et al (2011) Modulation of calcium-dependent inactivation of L-type Ca²⁺ channels via β-adrenergic signaling in thalamocortical relay neurons. PLoS One 6 e27474 PMID: 22164209

Lavine et al (2013) Attenuation of choroidal neovascularization by β(2)-adrenoreceptor antagonism. JAMA Ophthalmol 131 376 PMID: 23303344

Ataka et al (2013) Bone marrow-derived microglia infiltrate into the paraventricular nucleus of chronic psychological stress-loaded mice. PLoS One 8 e81744 PMID: 24303068

Nackley et al (2007) Catechol-O-methyltransferase inhibition increases pain sensitivity through activation of both beta2- and beta3-adrenergic receptors. Pain 128 199 PMID: 17084978

Maupoil et al (2007) Ectopic activity in the rat pulmonary vein can arise from simultaneous activation of alpha1- and beta1-adrenoceptors. Br J Pharmacol 150 899 PMID: 17325650

Cirino et al (2003) Involvement of β 3-adrenergic receptor activation via cyclic GMP- but not NO-dependent mechanisms in human corpus cavernosum function. Sci Rep 100 5531 PMID: 12707413

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