SR 8278

Cat. No. 4463 4 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Rev-Erbα antagonist

化学名： 1,2,3,4-Tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylic acid ethyl ester

纯度： ≥99% (HPLC)

引用文献 (4)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for SR 8278

SR 8278 is a Rev-Erbα antagonist; inhibits Rev-Erbα transcriptional repression (EC₅₀ = 0.47 μM). Blocks activity of Rev-Erbα agonist GSK 4112 (Cat. No. 3663) in HEK293 cells. Increases expression of glucose-regulating genes, G6Pase and PEPCK in HepG2 cells.

化合物库 for SR 8278

SR 8278 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for SR 8278

分子量	361.48
公式	C₁₈H₁₉NO₃S₂
储存	Store at +4°C
纯度	≥99% (HPLC)
CAS Number	1254944-66-5
PubChem ID	53393127
InChI Key	UIEBLUZPSFAFOC-UHFFFAOYSA-N
Smiles	CCOC(=O)C1CC2=CC=CC=C2CN1C(=O)C1=CC=C(SC)S1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SR 8278

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	36.15	100
	ethanol	18.07	50

制备储备液 for SR 8278

以下数据基于产品分子量 361.48。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.77 mL	13.83 mL	27.66 mL
5 mM	0.55 mL	2.77 mL	5.53 mL
10 mM	0.28 mL	1.38 mL	2.77 mL
50 mM	0.06 mL	0.28 mL	0.55 mL

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产品说明书 for SR 8278

分析证书/产品说明书

化学品安全技术说明书

参考文献 for SR 8278

参考文献是支持产品生物活性的出版物。

Kojetin et al (2011) Identification of SR8278, a synthetic antagonist of the nuclear heme receptor REV-ERB. ACS Chem. Biol. 6 131 PMID: 21043485

If you know of a relevant reference for SR 8278, please let us know.

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关键词: SR 8278, SR 8278 supplier, SR8278, REV-ERB, heme, nuclear, receptors, antagonists, inhibits, glucose, regulation, circadian, Rev-Erb, Receptors, 4463, Tocris Bioscience