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SR 9009

Cat. No. 5855 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Rev-Erbα/β agonist
化学名： Ethyl 3-[[[(4-chlorophenyl)methyl][(5-nitro-2-thienyl)methyl]amino]methyl]-1-pyrrolidinecarboxylate
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for SR 9009

SR 9009 is a Rev-Erbα/β agonist (EC50 = 710 nM; Kd = 800 nM). Alters circadian locomotor activity and core clock hypothalamic gene expression in mice. Induces weight loss in diet-induced obese mice. Brain penetrant.

化合物库 for SR 9009

SR 9009 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for SR 9009

分子量 437.94
公式 C20H24ClN3O4S
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 1379686-30-2
PubChem ID 57394020
InChI Key MMJJNHOIVCGAAP-UHFFFAOYSA-N
Smiles ClC(C=C1)=CC=C1CN(CC2CCN(C(OCC)=O)C2)CC3=CC=C([N+]([O-])=O)S3

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SR 9009

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 43.79 100
ethanol 43.79 100

制备储备液 for SR 9009

以下数据基于产品分子量 437.94。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.28 mL 11.42 mL 22.83 mL
5 mM 0.46 mL 2.28 mL 4.57 mL
10 mM 0.23 mL 1.14 mL 2.28 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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参考文献 for SR 9009

参考文献是支持产品生物活性的出版物。

Solt et al (2012) Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists. Nature 485 62 PMID: 22460951

Shin et al (2012) Small molecule tertiary amines as agonists of the nuclear hormone receptor Rev-erbα. Bioorg.Med.Chem.Lett. 22 4413 PMID: 22633688

If you know of a relevant reference for SR 9009, please let us know.

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关键词: SR 9009, SR 9009 supplier, SR9009, Rev-Erbalpha, Rev-Erba, Rev-Erbbeta, Rev-Erbb, Rev-Erbα, Rev-Erbβ, agonists, agonism, circadian, rhythm, antiobesity, brain, penetrant, Rev-Erb, Receptors, 5855, Tocris Bioscience

1 篇 SR 9009 的引用文献

引用文献是使用了 Tocris 产品的出版物。 SR 9009 的部分引用包括：

Hanne M et al (2022) Co-alterations of circadian clock gene transcripts in human placenta in preeclampsia. Sci Rep 12 17856 PMID: 36284122

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