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SR 9238

Cat. No. 5854 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective LXR inverse agonist
化学名： Ethyl 5-[[[[3'-(Methylsulfonyl)[1,1'-biphenyl]-4-yl]methyl][(2,4,6-trimethylphenyl)sulfonyl]amino]methyl]-2-furancarboxylate
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for SR 9238

SR 9238 is a potent and selective LXR inverse agonist (IC50 values are 43 and 214 nM for LXRβ and LXRα, respectively). Selectively inhibits liver LXR over peripheral LXR. Exhibits selectivity for LXR over a panel of 20 other nuclear receptors, including FXR. Reduces hepatic steatosis in obese mice.

化合物库 for SR 9238

SR 9238 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for SR 9238

分子量 595.73
公式 C31H33NO7S2
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 1416153-62-2
PubChem ID 71478195
InChI Key HDZWHJYZJWLTAG-UHFFFAOYSA-N
Smiles CCOC(C1=CC=C(O1)CN(S(=O)(C2=C(C=C(C=C2C)C)C)=O)CC3=CC=C(C4=CC(S(C)(=O)=O)=CC=C4)C=C3)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SR 9238

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 59.57 100

制备储备液 for SR 9238

以下数据基于产品分子量 595.73。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.68 mL 8.39 mL 16.79 mL
5 mM 0.34 mL 1.68 mL 3.36 mL
10 mM 0.17 mL 0.84 mL 1.68 mL
50 mM 0.03 mL 0.17 mL 0.34 mL

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参考文献 for SR 9238

参考文献是支持产品生物活性的出版物。

Griffett et al (2013) A liver-selective LXR inverse agonist that suppresses hepatic steatosis. ACS Chem.Biol. 8 559 PMID: 23237488

If you know of a relevant reference for SR 9238, please let us know.

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关键词: SR 9238, SR 9238 supplier, SR9238, potent, selective, LXR, inverse, agonist, liver, obesity, receptors, LXR-like, Receptors, 5854, Tocris Bioscience

2 篇 SR 9238 的引用文献

引用文献是使用了 Tocris 产品的出版物。 SR 9238 的部分引用包括：

Ning et al (2023) Nuclear receptor modulators inhibit osteosarcoma cell proliferation and tumour growth by regulating the mTOR signaling pathway. Cell Death Dis 14 51 PMID: 36681687

Bruschi et al (2019) PNPLA3 I148M Variant Impairs Liver X Receptor Signaling and Cholesterol Homeostasis in Human Hepatic Stellate Cells. Hepatol Commun 3 1191 PMID: 31497741

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