ST 034307

Cat. No. 6271 4 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Adenylyl cyclase 1 (AC1) inhibitor; analgesic and active in vivo

化学名： 6-Chloro-2-(trichloromethyl)-4H-1-benzopyran-4-one

纯度： ≥98% (HPLC)

引用文献 (4)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for ST 034307

ST 034307 is an adenylyl cyclase 1 (AC1) inhibitor (IC₅₀ = 2.3 μM). Exhibits some selectivity for AC1 over other AC isoforms, with no significant activity against AC8. Inhibits Ca²⁺/calmodulin-stimulated cAMP accumulation in hippocampal homogenates. Enhances μ opioid receptor (MOR)-mediated inhibition of AC1 in cellular assays and inhibits development and maintenance of MOR-mediated sensitization of AC1. ST 034307 relieves pain without causing tolerance in mouse models of pain. Active in vivo. Analgesic.

技术数据 for ST 034307

分子量	297.95
公式	C₁₀H₄Cl₄O₂
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	133406-29-8
PubChem ID	867466
InChI Key	NTDHYMSVCBGQJF-UHFFFAOYSA-N
Smiles	ClC1=CC=C2OC(C(Cl)(Cl)Cl)=CC(C2=C1)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ST 034307

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	29.8	100
	ethanol	5.96	20

制备储备液 for ST 034307

以下数据基于产品分子量 297.95。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	3.36 mL	16.78 mL	33.56 mL
5 mM	0.67 mL	3.36 mL	6.71 mL
10 mM	0.34 mL	1.68 mL	3.36 mL
50 mM	0.07 mL	0.34 mL	0.67 mL

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产品说明书 for ST 034307

分析证书/产品说明书

化学品安全技术说明书

参考文献 for ST 034307

参考文献是支持产品生物活性的出版物。

Brust et al (2017) Identification of a selective small-molecule inhibitor of type 1 adenylyl cyclase activity with analgesic properties. Sci.Signal. 10 eaah5381 PMID: 28223412

If you know of a relevant reference for ST 034307, please let us know.

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关键词: ST 034307, ST 034307 supplier, ST034307, adenylyl, cyclase, inhibitors, inhibits, AC1, active, in, vivo, analgesic, cAMP, Adenylyl, Cyclase, 6271, Tocris Bioscience