主页 / 药理学 / Enzymes / Transferases / Other Transferases / Other Transferase Inhibitors / ST 045849

ST 045849

Cat. No. 6775 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： O-GlcNAc transferase (OGT) inhibitor
化学名： 2-[(4-Chlorophenyl)imino]tetrahydro-4-oxo-3-(2-tricyclo[3.3.1.13,7]dec-1-ylethyl)-2H-1,3-thiazine-6-carboxylic acid
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for ST 045849

ST 045849 is an O-GlcNAc transferase (OGT) inhibitor (IC50 = 53 μM). Reduces proliferation and viability of prostate cancer cells in vitro. Depletes intracellular alanine and decreases glucose consumption by cancer cells. Decreases markers of ER stress and apoptosis in pregnant diabetic mice and reduces neural tube defects in embryos from diabetic mice.

技术数据 for ST 045849

分子量 446.99
公式 C23H27ClN2O3S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 442665-87-4
PubChem ID 4297469
InChI Key HLPZEZRNGAXCJH-UHFFFAOYSA-N
Smiles OC(C1CC(N(/C(S1)=N/C2=CC=C(C=C2)Cl)CCC34CC5CC(C4)CC(C3)C5)=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ST 045849

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 44.7 100
ethanol 44.7 100

制备储备液 for ST 045849

以下数据基于产品分子量 446.99。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.24 mL 11.19 mL 22.37 mL
5 mM 0.45 mL 2.24 mL 4.47 mL
10 mM 0.22 mL 1.12 mL 2.24 mL
50 mM 0.04 mL 0.22 mL 0.45 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

参考文献 for ST 045849

参考文献是支持产品生物活性的出版物。

Itkonen et al (2016) Inhibition of O-GlcNAc transferase activity reprograms prostate cancer cell metabolism. Oncotarget 7 12464 PMID: 26824323

Kim et al (2017) Impact of protein O-GlcNAcylation on neural tube malformation in diabetic embryopathy. Sci.Rep. 7 11107 PMID: 28894244

Kim et al (2014) Versatile O-GlcNAc transferase assay for high-throughput identification of enzyme variants, substrates, and inhibitors. Bioconjug.Chem. 25 1025 PMID: 24866374

If you know of a relevant reference for ST 045849, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Other Transferase Inhibitors

关键词: ST 045849, ST 045849 supplier, ST045849, O-GlcNAc, O-linked, N-acetylglucosamine, transferase, OGT, inhibitors, inhibits, glycosylation, glycolysis, O-GlcNAcylation, hyperglycemia, Other, Transferases, 6775, Tocris Bioscience

1 篇 ST 045849 的引用文献

引用文献是使用了 Tocris 产品的出版物。 ST 045849 的部分引用包括：

Edoardo et al (2022) O-GlcNAcylation enhances CPS1 catalytic efficiency for ammonia and promotes ureagenesis. Nat Commun 13 5212 PMID: 36064721

您是否知道使用了 Tocris ST 045849 的优秀论文？ 请告知我们.

ST 045849 的评论

目前没有该产品的评论。 Be the first to review ST 045849 and earn rewards!

Have you used ST 045849?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review