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Discontinued Product
6566 has been discontinued.
说明： AKAP disruptor; selectively binds PKA-RII and blocks its interaction with AKAP; cell permeable
生物活性 for STAD 2
STAD 2 is an AKAP disruptor. Selectively binds PKA-RII subunit with high affinity (Kd = 6.2 nM) and blocks its interaction with AKAP. Cell permeable. Selectively permeable to malaria-infected red blood cells and displays antimalarial activity through a PKA-independent mechanism.
技术数据 for STAD 2
| 分子量 | 2096.68 |
| 公式 | C102H182N24O22 |
| 序列 |
KKLAKFLVSXALKXALK (Modifications: Lys-1 = NH2-PEG3-CH2-CO-Lys, X = (S)-2-(4-pentenyl)alanine, X-10 and X-14 stapled together with a double bond) |
| 储存 | Store at -20°C |
| CAS Number | 1542100-77-5 |
| Smiles | CC(C[C@@H](C(N[C@H](C(N)=O)CCCCN)=O)NC([C@@H](NC([C@@]1(CCC/C=C/CCC[C@](NC([C@@H](NC([C@H](C(C)C)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(COCCOCCOCCN)=O)CCCCN)=O)CCCCN)=O)CC(C)C)=O)C)=O)CCCCN)=O)CC2=CC=CC=C2)=O)CC(C)C)=O)=O)CO)=O)(C(N[C@H](C(N[C@H](C(N[C@H](C(N1)=O)CCCCN)=O)CC(C)C)=O)C)=O)C)C)=O)C)=O)C |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for STAD 2
参考文献 for STAD 2
参考文献是支持产品生物活性的出版物。
Bendzunas et al (2018) Investigating PKA-RII specificity using analogs of the PKA:AKAP peptide inhibitor STAD-2. Bioorg.Med.Chem. 26 1174 PMID: 29449124
Flaherty et al (2015) The stapled AKAP disruptor peptide STAD-2 displays antimalarial activity through a PKA-independent mechanism. PLoS One 10 e0129239 PMID: 26010880
Wang et al (2014) Isoform-selective disruption of AKAP-localized PKA using hydrocarbon stapled peptides. ACS Chem.Biol. 9 635 PMID: 24422448
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关键词: STAD 2, STAD 2 supplier, STAD2, stapled, peptide, selective, AKAP, disruptors, disrupts, a-kinase, anchoring, proteins, RII, antimalarial, PKA, protein, kinase, A, A-kinase-anchoring, protiens, Antimalarials, Stapled, Peptides, 6566, Tocris Bioscience
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