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Submit ReviewSTF 118804
说明： NAMPT inhibitor; depletes leukemia stem cells
化学名： 4-[5-Methyl-4-[[(4-methylphenyl)sulfonyl]methyl]-2-oxazolyl]-N-(3-pyridinylmethyl)benzamide
纯度： ≥98% (HPLC)
生物活性 for STF 118804
STF 118804 is a NAMPT inhibitor (nicotinamide phosphoribosyltransferase, visfatin, PBEF1); inhibits NAD+ synthesis from nicotinamide. Potently inhibits the viability of multiple B-cell acute lymphoplastic leukemia (B-ALL) cell lines (IC50 < 10 nM); induces apoptosis in MF-411 cells. Induces regression of ALL xenografts and eliminates leukemia stems cells from bone marrow in mice.
技术数据 for STF 118804
| 分子量 | 461.53 |
| 公式 | C25H23N3O4S |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 894187-61-2 |
| PubChem ID | 20916937 |
| InChI Key | DLFCEZOMHBPDGI-UHFFFAOYSA-N |
| Smiles | O=C(C2=CC=C(C3=NC(CS(C4=CC=C(C)C=C4)(=O)=O)=C(C)O3)C=C2)NCC1=CN=CC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for STF 118804
参考文献 for STF 118804
参考文献是支持产品生物活性的出版物。
Matheny et al (2013) Next-generation NAMPT inhibitors identified by sequential high-throughput phenotypic chemical and functional genomic screens. Chem.Biol. 20 1352 PMID: 24183972
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关键词: STF 118804, STF 118804 supplier, STF118804, NAMPT, inhibitors, inhibits, potent, nicotinamide, phosphoribosyltransferase, visfatin, PBEF1, cytotoxic, Cancer, Stem, Cells, 5207, Tocris Bioscience
1 篇 STF 118804 的引用文献
引用文献是使用了 Tocris 产品的出版物。 STF 118804 的部分引用包括：
Fons et al (2019) PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma. Nat Commun 10 3790 PMID: 31439867
STF 118804 的评论
平均评分: 5 (Based on 1 Review.)
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It works well for cell culture..
By
Anonymous on 05/07/2020
分析类型： In Vitro
种属： Human
细胞系/组织： human astrocytes
After 72hr treatment with three different inhibitors (GPP78,STF118804, and STF31), we used 10nM to 10uM.
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