STING agonist C53

Cat. No. 7741 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Pan-polymorph STING agonist

化学名： 1-[(2-Chloro-6-fluorophenyl)methyl]-2,3-dihydro-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-1H-indole-6-carboxamide

纯度： ≥98% (HPLC)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for STING agonist C53

STING agonist C53 is an activator of human STING (EC₅₀ = 185 nM). It promotes the oligomerization and activation of human STING through a mechanism orthogonal to that of cGAMP. STING agonist C53 increases activity of STING variants in HEK293T cells (107%, 92% and 92% reporter activity against H232, R232 and HAQ, respectively). It induces phosphorylation of STING variants in human tumor cell lines and PBMCs. STING agonist C53 is active at human but not mouse STING. Orally bioavailable.

化合物库 for STING agonist C53

STING agonist C53 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for STING agonist C53

分子量	490.88
公式	C₂₅H₁₉ClF₄N₂O₂
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	2259624-71-8
PubChem ID	137367538
InChI Key	OEBVYNULNKSONR-UHFFFAOYSA-N
Smiles	CC1(C(N(C2=CC(C(NCC3=C(C=C(C=C3F)F)F)=O)=CC=C12)CC4=C(C=CC=C4F)Cl)=O)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for STING agonist C53

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	49.09	100

制备储备液 for STING agonist C53

以下数据基于产品分子量 490.88。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.04 mL	10.19 mL	20.37 mL
5 mM	0.41 mL	2.04 mL	4.07 mL
10 mM	0.2 mL	1.02 mL	2.04 mL
50 mM	0.04 mL	0.2 mL	0.41 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

产品说明书 for STING agonist C53

分析证书/产品说明书

化学品安全技术说明书

参考文献 for STING agonist C53

参考文献是支持产品生物活性的出版物。

Pryde et al (2021) The discovery of potent small molecule activators of human STING. Eur.J.Med.Chem. 209 112869 PMID: 33038794

Lu et al (2022) Activation of STING by targeting a pocket in the transmembrane domain. Nature 604 557 PMID: 35388221

If you know of a relevant reference for STING agonist C53, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 STING-Dependent Signaling Agonists

关键词: STING agonist C53, STING agonist C53 supplier, stingagonistc53, Promotes, promoters, oligomerization, activation, human, STING, pan, polymorph, STING-Dependent, Signaling, 7741, Tocris Bioscience

篇 STING agonist C53 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 STING agonist C53 的引用文献。您是否知道使用了 Tocris STING agonist C53 的优秀论文？请告知我们.