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STX 64

Cat. No. 7341 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent steroid sulfatase inhibitor; also inhibits carbonic anhydrase II
化学名： 6,7,8,9,10,11-Hexahydro-6-oxobenzo[b]cyclohepta[d]pyran-3-yl sulfamate
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for STX 64

STX 64 is a potent steroid sulfatase inhibitor (IC50 = 8 nM). Estrone sulfate-stimulated uterine growth and mammary tumor growth are inhibited by STX 64 in animal models. STX 64 shows inhibition of steroid sulfatase activity in peripheral blood lymphocytes, liver and tumor tissues and is active in vivo. STX 64 is also a potent inhibitor of carbonic anhydrase II (IC50 = 25 nM).

化合物库 for STX 64

STX 64 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for STX 64

分子量 309.34
公式 C14H15NO5S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 288628-05-7
PubChem ID 5287541
InChI Key DSLPMJSGSBLWRE-UHFFFAOYSA-N
Smiles O=C1OC=2C=C(OS(=O)(=O)N)C=CC2C3=C1CCCCC3

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for STX 64

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 30.93 100
ethanol 3.09 10

制备储备液 for STX 64

以下数据基于产品分子量 309.34。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.23 mL 16.16 mL 32.33 mL
5 mM 0.65 mL 3.23 mL 6.47 mL
10 mM 0.32 mL 1.62 mL 3.23 mL
50 mM 0.06 mL 0.32 mL 0.65 mL

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参考文献 for STX 64

参考文献是支持产品生物活性的出版物。

Ho et al (2003) Inhibition of carbonic anhydrase II by steroidal and non-steroidal sulphamates. Biochem.Biophys.Res.Commun. 305 909 PMID: 12767917

Purohit et al (2000) In vivo inhibition of estrone sulfatase activity and growth of nitrosomethylurea-induced mammary tumors by 667 COUMATE. Cancer Res. 60 3394 PMID: 10910045

Raobaikady et al (2003) Inhibition of MCF-7 breast cancer cell proliferation and in vivo steroid sulphatase activity by 2-methoxyoestradiol-bis-sulphamate. J.Steroid Biochem.Mol.Biol. 84 351 PMID: 12711022

If you know of a relevant reference for STX 64, please let us know.

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关键词: STX 64, STX 64 supplier, STX64, potent, steroid, sulfatase, inhibitors, inhibits, esterases, tumor, carbonic, anhydrase, EC3.1.6.2, steryl-sulfatase, Other, Hydrolases, Carbonic, anhydrases, 7341, Tocris Bioscience

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