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Submit ReviewSU 4312
说明： Potent inhibitor of VEGFR tyrosine kinase
别名： DMBI
化学名： 3-[[4-(dimethylamino)phenyl]methylene]-1,3-dihydro-2H-indol-2-one
生物活性 for SU 4312
SU 4312 is a potent and selective inhibitor of VEGFR and PDGFR tyrosine kinases (IC50 values are 0.8 and 19.4 μM respectively). Selective over EGFR and c-Src tyrosine kinases.
技术数据 for SU 4312
| 分子量 | 264.33 |
| 公式 | C17H16N2O |
| 储存 | Desiccate at -20°C |
| CAS Number | 5812-07-7 |
| PubChem ID | 6450842 |
| InChI Key | UAKWLVYMKBWHMX-PTNGSMBKSA-N |
| Smiles | CN(C)C1=CC=C(C=C1)\C=C1/C(=O)NC2=CC=CC=C12 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for SU 4312
参考文献 for SU 4312
参考文献是支持产品生物活性的出版物。
Kendall et al (1999) Vascular endothelial growth factor receptor KDR tyrosine kinase activity is increased by autophosphorylation of two activation loop tyrosine residues. J.Biol.Chem. 274 6453 PMID: 10037737
Sun et al (1998) Synthesis and biological evaluations of 3-substituted indol-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases. J.Med.Chem. 41 2588 PMID: 9651163
Zaman et al (1998) Tyrosine kinase activity of purified recombinant cytoplasmic domain of platelet-derived growth factor β-receptor (β-PDGFR) and discovery of a novel inhibitor of receptor tyrosine kinases. Biochem.Pharmacol. 57 57 PMID: 9920285
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关键词: SU 4312, SU 4312 supplier, Potent, inhibitors, inhibits, VEGFR, tyrosine, kinase, Vascular, Endothelial, Growth, Factor, Receptors, KDR, Flt, Receptor, Tyrosine, Kinases, RTKs, SU4312, DMBI, 1459, Tocris Bioscience
1 篇 SU 4312 的引用文献
引用文献是使用了 Tocris 产品的出版物。 SU 4312 的部分引用包括：
Cole et al (2010) Synthetic heparan sulfate oligosaccharides inhibit endothelial cell functions essential for angiogenesis. PLoS One 5 e11644 PMID: 20657775
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Angiogenesis in Cancer Poster
This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.
Pathways for SU 4312
