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Submit ReviewSU 5402
说明： Potent FGFR and VEGFR inhibitor
化学名： 2-[(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl]-4-methyl-1H-pyrrole-3-propanoic acid
纯度： ≥95% (HPLC)
生物活性 for SU 5402
SU 5402 is a potent and selective vascular endothelial growth factor receptor (VEGFR) and fibroblast growth factor receptor (FGFR) inhibitor (IC50 values are 0.02, 0.03, 0.51 and > 100 μM at VEGFR2, FGFR1, PDGFRβ and EGFR respectively). Inhibits embryonic left-right determination and exhibits potent anticancer activity in vitro and in vivo. Also attenuates integrin β4-induced differentiation of neural stem cells. Supports mESC self-renewal.
For more information about how SU 5402 may be used, see our protocol: Accelerated Induction of Cortical Neurons from hiPSCs
技术数据 for SU 5402
| 分子量 | 296.32 |
| 公式 | C17H16N2O3 |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 215543-92-3 |
| PubChem ID | 5289418 |
| InChI Key | JNDVEAXZWJIOKB-JYRVWZFOSA-N |
| Smiles | CC1=CNC(\C=C(C2=CC=CC=C2N3)/C3=O)=C1CCC(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for SU 5402
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 29.63 | 100 |
制备储备液 for SU 5402
以下数据基于产品分子量 296.32。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.37 mL | 16.87 mL | 33.75 mL |
| 5 mM | 0.67 mL | 3.37 mL | 6.75 mL |
| 10 mM | 0.34 mL | 1.69 mL | 3.37 mL |
| 50 mM | 0.07 mL | 0.34 mL | 0.67 mL |
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产品说明书 for SU 5402
参考文献 for SU 5402
参考文献是支持产品生物活性的出版物。
Sun et al (1999) Design, synthesis and evaluations of substituted 3-[(3- or 4-carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as inhibitors of VEGF, FGF and PDGF receptor tyrosine kinases. J.Med.Chem. 42 5120 PMID: 10602697
Paterson et al (2004) Preclinical studies of fibroblast growth factor receptor 3 as a therapeutic target in multiple myeloma. Br.J.Haematol. 124 595 PMID: 14871245
Tanaka et al (2005) FGF-induced vesicular release of sonic hedgehog and retinoic acid in leftward nodal flow is critical for left-right determination. Nature 435 172 PMID: 15889083
Su et al (2009) Neural stem cell differentiation is mediated by integrin beta4 in vitro. Int.J.Biochem.Cell Biol. 41 916 PMID: 18834954
Buehr et al (2008) Capture of authentic embryonic stem cells from rat blastocysts. Cell 135 1287 PMID: 19109897
If you know of a relevant reference for SU 5402, please let us know.
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关键词: SU 5402, SU 5402 supplier, Potent, VEGFR, FGFR, inhibitors, inhibits, Vascular, Endothelial, Growth, Factor, Receptors, KDR, Flt, Receptor, Tyrosine, Kinases, RTKs, Fibroblast, SU5402, neural, stem, cells, differentiation, Neural, Stem, Cells, Cell, Proliferation, 3300, Tocris Bioscience
18 篇 SU 5402 的引用文献
引用文献是使用了 Tocris 产品的出版物。 SU 5402 的部分引用包括：
Rodrigues (2017) Integration of Shh and Fgf signaling in controlling Hox gene expression in cultured limb cells. PNAS 114 3139 PMID: 28270602
Hashiguchi and Mullins (2013) Anteroposterior and dorsoventral patterning are coordinated by an identical patterning clock. Development 140 1970 PMID: 23536566
Clanton et al (2013) Fgf signaling governs cell fate in the zebrafish pineal complex. Development 140 323 PMID: 23250206
Borroto-Escuela et al (2012) The existence of FGFR1-5-HT1A receptor heterocomplexes in midbrain 5-HT neurons of the rat: relevance for neuroplasticity. J Neurosci 32 6295 PMID: 22553035
Li et al (2016) FGF1 Mediates Overnutrition-Induced Compensatory β-Cell Differentiation. Diabetes 65 96 PMID: 26420862
Gibb et al (2018) Hey2 regulates the size of the cardiac progenitor pool during vertebrate heart development. Development 145 PMID: 30355727
Rankin et al (2012) Suppression of Bmp4 signaling by the zinc-finger repressors Osr1 and Osr2 is required for Wnt/β-catenin-mediated lung specification in Xenopus. Cell Mol Life Sci 139 3010 PMID: 22791896
Benzina et al (2015) A kinome-targeted RNAi-based screen links FGF signaling to H2AX phosphorylation in response to radiation. PLoS One 72 3559 PMID: 25894690
Neugebauer and Yost (2014) FGF signaling is required for brain left-right asymmetry and brain midline formation. Dev Biol 386 123 PMID: 24333178
Dai et al (2014) Calcium deficiency-induced and TRP channel-regulated IGF1R-PI3K-Akt signaling regulates abnormal epithelial cell proliferation. Cell Death Differ 21 568 PMID: 24336047
Chen (2014) The development of zebrafish tendon and ligament progenitors. Development 141 2035 PMID: 24803652
Sato et al (2011) FGF8 signaling is chemotactic for cardiac neural crest cells. Neural Dev 354 18 PMID: 21419761
Tan et al (2011) Generation of trophoblast stem cells from rabbit embryonic stem cells with BMP4. Nat Med 6 e17124 PMID: 21359200
Yan et al (2017) Chemical inhibition reveals differential requirements of signaling pathways in krasV12- and Myc-induced liver tumors in transgenic zebrafish. Sci Rep 7 45796 PMID: 28378824
Yang et al (2017) Establishment of mouse expanded potential stem cells. Nature 550 393 PMID: 29019987
Cunningham et al (2015) Retinoic Acid Activity in Undifferentiated Neural Progenitors Is Sufficient to Fulfill Its Role in Restricting Fgf8 Expression for Somitogenesis. PLoS One 10 e0137894 PMID: 26368825
Bernet et al (2014) p38 MAPK signaling underlies a cell-autonomous loss of stem cell self-renewal in skeletal muscle of aged mice. Dev Biol 20 265 PMID: 24531379
Dean et al (2014) Dbx1b defines the dorsal habenular progenitor domain in the zebrafish epithalamus. Stem Cell Res Ther 9 20 PMID: 25212830
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Stem Cell Research Product Guide
This product guide provides a background to the use of small molecules in stem cell research and lists over 200 products for use in:
- Self-renewal and Maintenance
- Differentiation
- Reprogramming
- Organoid Generation
- GMP and Ancillary Material Grade Products
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Angiogenesis in Cancer Poster
This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Stem Cells Poster
Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.